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Article
Bayesian Learning of Personalized Longitudinal Biomarker Trajectory
This work concerns the effective personalized prediction of longitudinal biomarker trajectory, motivated by a study of cancer targeted therapy for patients with chronic myeloid leukemia (CML). Continuous monit...
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Article
Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields
Transcranial alternating current stimulation (tACS) is widely used in studying brain functions and the treatment of neuropsychiatric diseases in a frequency-specific manner. However, how tACS works on neuronal...
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Article
Open AccessCASi: A framework for cross-timepoint analysis of single-cell RNA sequencing data
Single-cell RNA sequencing (scRNA-seq) technology has been widely used to study the differences in gene expression at the single cell level, providing insights into the research of cell development, differenti...
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Article
Open AccessAssociation between plasma metal exposure and health span in very elderly adults: a prospective cohort study with mixture statistical approach
Metals have been linked to a diverse spectrum of age-related diseases; however, the effects of metal exposure on health span remains largely unknown. This cohort study aims to determine the association between...
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Article
Exploring the impact of motivations on individual online and offline preventive actions against COVID-19
Having accurate and sufficient information about the outbreak and actively adopting preventive actions are important to reduce the adverse effects of COVID-19 and control the spread of the epidemic. To this en...
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Article
Open AccessAssociation and mediation between educational attainment and respiratory diseases: a Mendelian randomization study
Respiratory diseases are a major health burden, and educational inequalities may influence disease prevalence. We aim to evaluate the causal link between educational attainment and respiratory disease, and to ...
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Article
Open AccessCOVID-19 information seeking and individuals’ protective behaviors: examining the role of information sources and information content
Seeking COVID-19 information promotes individuals to adopt preventive behaviors, including wearing a mask, social distancing, staying away from risky places, and washing hands. This study aims to investigate w...
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Chapter and Conference Paper
Optimization Design of Preforming Geometric Parameters for Cantilever Ring with Complex Structure
The inhomogeneity of the metal continuous grain flow in preformed blank with complex structured cantilever ring is determined by billet geometrical parameters. In this paper, the influence of the geometric par...
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Article
Task-space Whole-body Control with Variable Contact Force Control for Position-controlled Humanoid Adaptation to Unknown Disturbance
Whole-body control is beneficial for improving the disturbance adaptation of humanoid robots, since it can simultaneously optimize desired joint torque, joint acceleration, and contact force while considering ...
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Article
Wear indicator construction for rolling bearings based on an enhanced and unsupervised stacked auto-encoder
The degradation state of a bearing can be monitored effectively by using a wear indicator (WI). A WI curve having smoothness and monotonicity can lay a good foundation for predicting the remaining useful life ...
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Article
Long-Term Exposure to Traffic Noise and Risk of Incident Cardiovascular Diseases: a Systematic Review and Dose-Response Meta-Analysis
While noise pollution from transportation has become an important public health problem, the relationships between different sources of traffic noise and cardiovascular diseases (CVDs) remain inconclusive. A c...
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Article
Open AccessA phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents
Pevonedistat is a first-in-class, small molecular inhibitor of NEDD8-activating enzyme that has clinical activity in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Preclinical data suggest s...
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Article
The impact of natural resource consumption on carbon emissions: evidence of a symmetric and asymmetric effect from Sub-Saharan Africa
Sub-Saharan African countries are among mineral-rich develo** countries strategically competing to guarantee sustainable economic development through resource exploration. The possibility of increasing the l...
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Article
Conservation and sustainable development of coastal species of horticultural importance: insights from genetic and environmental patterns at spatio-temporal scale
Understanding genetic patterns at the regional level and the environmental influence on them is important for the conservation and sustainable use of economically important plant species. In this study, we foc...
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Article
Open AccessCorrection: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
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Article
Open AccessCombined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
TP53-mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and rever...
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Article
Open AccessComprehensive analysis of the laccase gene family in tea plant highlights its roles in development and stress responses
Laccase (LAC) is the pivotal enzyme responsible for the polymerization of monolignols and stress responses in plants. However, the roles of LAC genes in plant development and tolerance to diverse stresses are ...
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Article
Constructing a health indicator based on long short-term memory and using an extreme inflection point with a slope model to enhance monotonicity
Traditional health indicator (HI) construction methods usually require manual feature selection and fusion, and different models are selected for combination; therefore, a large amount of expert experience and...
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Chapter and Conference Paper
Optimization of Whole-Body Motion for Humanoid Robot Walking Down Stairs with Small Joint Range of Motion
Traversing through stairs stably is a challenging task for humanoid locomotion. Previous researches mostly focus on empowering humanoid robots with the capability of walking up stairs. There are only a few stu...
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Article
Association of hematologic response and assay sensitivity on the prognostic impact of measurable residual disease in acute myeloid leukemia: a systematic review and meta-analysis
Measurable residual disease (MRD) is associated with relapse and survival in acute myeloid leukemia (AML). We aimed to quantify the impact of MRD on outcomes across clinical contexts, including its association...
