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Article
Open AccessInvestigation on the molecular mechanism of SPA interference with osteogenic differentiation of bone marrow mesenchymal stem cells
Binding of Staphylococcus aureus protein A (SPA) to osteoblasts induces apoptosis and inhibits bone formation. Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into bone, fa...
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Article
Structural elucidation a complex galactosyl and glucosyl-rich pectin from the pericarp of immature fruits of Juglans mandshurica Maxim.
A glucosyl-rich pectin, JMMP-3 (Mw, 2.572 × 104 g/mol, O-methyl % = 3.62%), was isolated and purified from the pericarp of the immature fruit of Juglans mandshurica Maxim. (QingLongYi). The structure of JMMP-3 wa...
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Article
Volume-averaged modeling of multiphase solidification with equiaxed crystal sedimentation in a steel ingot
Macrosegregation is a critical factor that limits the mechanical properties of materials. The impact of equiaxed crystal sedimentation on macrosegregation has been extensively studied, as it plays a significan...
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Article
Autonomous gait switching method and experiments of a hexapod walking robot for Mars environment with multiple terrains
Mars exploration significantly advances our understanding of planetary evolution, the origin of life, and possibilities for Earth’s future. It also holds potential for discovering new mineral resources, energy...
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Article
Open AccessA simple and economic method to modify large organic surfaces for enhancing adhesion and transparent Au/PMMA with high electromagnetic shielding efficiency
This study introduces a simple and cost-effective approach for modifying large organic surfaces, facilitating robust adhesion between Au films and polymethyl methacrylate (PMMA) while retaining transparency to...
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Article
Age transformation based on deep learning: a survey
Age transformation aims to preserve personalized facial information while altering a given face to appear at a target age. This technique finds extensive applications in fields such as face recognition, movie ...
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Article
Open AccessDirect osteosynthesis in the treatment of atlas burst fractures: a systematic review
The treatment of unstable atlas fractures remains a controversial topic. The study aims at assessing the prognosis and efficacy of osteosynthesis for unstable atlas fractures through a review of the current li...
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Article
Open AccessDesign of a novel lateral mass screw–plate system for the treatment of unstable atlas fractures: a finite element analysis
Osteosynthesis of unstable atlas fractures preserves joint motion and therefore has a distinct advantage over a range of treatment procedures. To prevent the potential disadvantages associated with osteosynthe...
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Article
Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia
M1 microglial activation is crucial for the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH), and there is growing evidence that glucose metabolism is frequently involved in mic...
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Article
Open AccessA dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robust transmission-blocking activity
Despite years of effort to develop an effective vaccine against malaria infection, a vaccine that provides individuals with sufficient protection against malaria illness and death in endemic areas is not yet a...
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Article
Effect of Nb Do** on Thermoelectric Properties of TiNiSn Half-Heusler Alloy Prepared by Microwave Method
The inherent high thermal conductivity of TiNiSn half-Heusler (HH) alloy, as well as the long preparation cycle time and high cost of conventional preparation methods limited its commercial application. Herein...
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Article
Experimental study on shear failure mechanism of loose spoil soil considering the adverse factor of water
Loose spoil soil (LSS) is a kind of granular material with unstable structure, for which the deformation and even failure should be induced by changing of water conditions. This research was conducted based on...
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Article
Fundicoccus culcitae sp. nov., a novel potential bacteriocin producing bacterium isolated from a spoiled eye mask
A Gram-positive, facultatively anaerobic, oval beaded-shape, oxidase-negative, and non-motile bacterium designated DM20194951T was isolated from a spoiled eye mask obtained from Guangdong, China. Based on the 16S...
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Article
Safety and efficacy of microwave ablation for the treatment of low-risk papillary thyroid microcarcinoma: a prospective multicenter study
To assess the safety and efficacy of ultrasound-guided thermal ablation for low-risk papillary thyroid microcarcinoma (PTMC) via a prospective multicenter study.
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Article
A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart
Tamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing in rodent hearts. However, little is known about the baselin...
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Article
Open AccessContribution of the Chinese Meridian Project to space environment research: Highlights and perspectives
The Chinese Meridian Project (CMP) is devoted to establishing a comprehensive ground-based monitoring network for China’s space weather research. CMP is a major national science and technology infrastructure p...
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Article
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway
Proteasomes are overexpressed in multiple myeloma (MM) and proteasomal inhibitors (PIs) have been widely used for the treatment of MM. PIs are reported to induce MM cell apoptosis but impair necroptosis. In th...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessThalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus
The thalamocortical (TC) circuit is closely associated with pain processing. The hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel is predominantly expressed in the ventral posterolateral tha...
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Article
Low-thermal-budget synthesis of monolayer molybdenum disulfide for silicon back-end-of-line integration on a 200 mm platform
Two-dimensional (2D) materials are promising candidates for future electronics due to their excellent electrical and photonic properties. Although promising results on the wafer-scale synthesis (≤150 mm diamet...
