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Open AccessDetection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system
Atherosclerosis is the build-up of fatty plaques within blood vessel walls, which can occlude the vessels and cause strokes or heart attacks. It gives rise to both structural and biomolecular changes in the ve...
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Open AccessDetection of fucosylated extracellular vesicles miR-4732-5p related to diagnosis of early lung adenocarcinoma by the electrochemical biosensor
Our preliminary investigation has identified the potential of serum fucosylated extracellular vesicles (EVs) miR-4732-5p in the early diagnosis of lung adenocarcinoma (LUAD) by a fucose-captured strategy utili...
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Open AccessFOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma1–4, but the efficacy of CAR ...
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Open AccessDurable Janus membrane with on-demand mode switching fabricated by femtosecond laser
Despite their notable unidirectional water transport capabilities, Janus membranes are commonly challenged by the fragility of their chemical coatings and the clogging of open microchannels. Here, an on-demand...
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Open AccessQuantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections
Chiral sensing of single molecules is vital for the understanding of chirality and their applications in biomedicine. However, current technologies face severe limitations in achieving single-molecule sensitiv...
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Open AccessMagnetic Janus origami robot for cross-scale droplet omni-manipulation
The versatile manipulation of cross-scale droplets is essential in many fields. Magnetic excitation is widely used for droplet manipulation due to its distinguishing merits. However, facile magnetic actuation ...
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Open AccessLight-triggered multi-joint microactuator fabricated by two-in-one femtosecond laser writing
Inspired by the flexible joints of humans, actuators containing soft joints have been developed for various applications, including soft grippers, artificial muscles, and wearable devices. However, integrating...
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Open AccessSystems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression
Depression is a common mental disease, with some patients exhibiting ideas and behaviors such as self-harm and suicide. The drugs currently used to treat depression have not achieved good results. It has been ...
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Open AccessAuthor Correction: High-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile
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Open AccessHigh-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile
Miniaturized rotors based on Marangoni effect have attracted great attentions due to their promising applications in propulsion and power generation. Despite intensive studies, the development of Marangoni rot...
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Article
Open AccessStructure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation
Stomata play a critical role in the regulation of gas exchange and photosynthesis in plants. Stomatal closure participates in multiple stress responses, and is regulated by a complex network including abscisic...
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Open AccessEfficient room temperature catalytic synthesis of alternating conjugated copolymers via C-S bond activation
Structural defects in conjugated copolymers are severely detrimental to the optoelectronic properties and the performance of the resulting electronic devices fabricated from them. Therefore, the much-desired p...
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Open AccessAssessment of vegetation growth and drought conditions using satellite-based vegetation health indices in **g-**-Ji region of China
Terrestrial vegetation growth activity plays pivotal roles on regional development, which has attracted wide attention especially in water resources shortage areas. The paper investigated the spatiotemporal ch...
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Open AccessAssociation between physical exercise and stroke recurrence among first-ever ischemic stroke survivors
The relationship between exercise and stroke recurrence is controversial. This study was designed to test whether an association exists between exercise and ischemic stroke recurrence in first-ever ischemic st...
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Open AccessConjugated Polymer Controlled Morphology and Charge Transport of Small-Molecule Organic Semiconductors
In this study, we report an effective approach to tune the crystallization, microstructure and charge transport of solution-processed organic semiconductors by blending with a conjugated polymer additive poly(...
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Open AccessDevelopment of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
Cyclotron-produced astatine-211 (211At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay....
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Open AccessInvestigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system
Astatine-211 is an attractive radionuclide for use in targeted alpha therapy of blood-borne diseases and micrometastatic diseases. Efficient isolation methods that can be adapted to robust automated 211At isolati...
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Open AccessEfficient nonlinear beam sha** in three-dimensional lithium niobate nonlinear photonic crystals
Nonlinear beam sha** refers to spatial reconfiguration of a light beam at a new frequency, which can be achieved by using nonlinear photonic crystals (NPCs). Direct nonlinear beam sha** has been achieved t...
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Open AccessLoading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood
Recent studies have demonstrated that antibiotics/or probiotics administration in early life play key roles on modulating intestinal microbiota and the alterations might cause long-lasting consequences both ph...
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Open AccessUltrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor
MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis and metastasis. Although fluorescence techniques using dye molecule labels have been studied, l...