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Article
Open AccessA novel PH1/pE27HGFK1 nanoparticles for orthotopic glioblastoma therapy
The therapeutic resistance to ionizing radiation (IR) and angiogenesis inhibitors is a great challenge for clinicians in the treatment of glioblastoma, which is associated with Hepatocyte growth factor (HGF)/M...
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Article
Open AccessSurvival Analysis and Immune Differences of HIV Long-Term Non-progressors in **njiang China: A 12-Year Prospective Cohort Observation
This 12-year cohort study of 80 long-term non-progressors (LTNPs) observed a cumulative follow-up duration of 628.5 person-years. Among them, 60 received antiretroviral therapy (ART) for a total of 418.6 perso...
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Article
Open AccessThe predictive accuracy of machine learning for the risk of death in HIV patients: a systematic review and meta-analysis
Early prediction of mortality in individuals with HIV (PWH) has perpetually posed a formidable challenge. With the widespread integration of machine learning into clinical practice, some researchers endeavor t...
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Chapter and Conference Paper
Cross-Correlation Based Trace Segmentation for Clustering Power Analysis on Public Key Cryptosystems
Simple Power Analysis (SPA) is a technique that directly analyzes the power consumption information collected during the execution of cryptographic algorithms. It is primarily based on the fact that different ...
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Article
Open AccessNanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiov...
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Article
Open AccessStructural insights into ligand recognition and selectivity of somatostatin receptors
Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating hormone, and thus are considered as targets for treating mult...
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Article
Attitude stability control of UAV gyroscope based on neutral statistics for smart cities
The usage of Unmanned Aerial Vehicle (UAV) is growing in defense, industry and smart cities as UAVs are airborne systems and are utilized to provide vital information promptly. UAVs are operated by automated m...
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Article
Identification of methylation markers for diagnosis of autism spectrum disorder
Autism spectrum disorder (ASD) is a hereditary heterogeneous neurodevelopmental disorder characterized by social and speech dysplasia. We collected the expression profiles of ASD in GSE26415, GSE42133 and GSE1...
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Article
Open AccessIdentification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China
The discovery of new viruses is important for predicting their potential threats to the health of humans and other animals. A novel picornavirus was identified from oral, throat, and anal swab samples collecte...
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Article
Phylogenetic Analysis of the Dengue Virus Strains Causing the 2019 Dengue Fever Outbreak in Hainan, China
Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes spp. mosquitos, causing the acute infectious disease, dengue fever (DF). Until 2019, no dengue outbreak had been report...
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Chapter and Conference Paper
Balancing Exploration and Exploitation in the Memetic Algorithm via a Switching Mechanism for the Large-Scale VRPTW
This paper presents an effective memetic algorithm for the large-scale vehicle routing problem with time windows (VRPTW). Memetic algorithms consist of an evolutionary algorithm for the global exploration and ...
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Chapter and Conference Paper
Trajectory Anomaly Detection Based on the Mean Distance Deviation
With the development of science and technology and the explosive growth of data, there will be a lot of trajectories every day. However, how to detect the abnormal trajectory from many trajectories has become ...
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Article
Double quantitative fuzzy rough set-based improved AHP method and application to supplier selection decision making
Selecting excellent supplier is the foundation of establishing efficient supply chain. This paper presents a novel hybrid model for supplier selection decision making problem by combining double quantitative f...
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Article
Open AccessMicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats
Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, the therapeutic efficiency of bone marrow-de...
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Article
In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus
Currently, more antimicrobial drug candidates are urgently needed to combat the rise in drug-resistance among pathogenic microbes. A new antimicrobial peptide, MP1102, a variant of NZ2114, was designed, evalua...
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Article
Ionic liquid-based hollow fiber liquid-phase microextraction for the determination of trace lead (II) in environmental water and tea drinks samples by graphite furnace atomic absorption spectrometry
A three-phase hollow fiber liquid-phase microextraction (HF-LPME) was used to determine the trace amounts of Lead (II) in environmental water and tea drinks. In this approach, green solvent ionic liquid 1-hexy...
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Article
Open AccessBiotechnical paving of recombinant enterocin A as the candidate of anti-Listeriaagent
Enterocin A is a classic IIa bacteriocin isolated firstly from Enterococcus faecium CTC492 with selective antimicrobial activity against Listeria strains. However, the application of enterocin A as an anti-Lister...
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Article
High expression of a plectasin-derived peptide NZ2114 in Pichia pastoris and its pharmacodynamics, postantibiotic and synergy against Staphylococcus aureus
NZ2114, a new variant of plectasin, was overexpressed in Pichia pastoris X-33 via pPICZαA for the first time. The total secreted protein of fermentation supernatant reached 2,390 mg/l (29 °C) and 2,310 mg/l (25 °...
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Article
Erratum to: Design, expression, and characterization of a novel targeted plectasin against methicillin-resistant Staphylococcus aureus
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Article
Design, expression, and characterization of a novel targeted plectasin against methicillin-resistant Staphylococcus aureus
A novel specifically targeted antimicrobial peptide (STAMP) that was especially effective against methicillin-resistant Staphylococcus aureus (MRSA) was designed by fusing the AgrD1 pheromone to the N-terminal en...
