Skip to main content

and
  1. Article

    Open Access

    DG-Affinity: predicting antigen–antibody affinity with language models from sequences

    Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer ...

    Ye Yuan, Qushuo Chen, Jun Mao, Guipeng Li, **aoyong Pan in BMC Bioinformatics (2023)

  2. Article

    Open Access

    RBPsuite: RNA-protein binding sites prediction suite based on deep learning

    RNA-binding proteins (RBPs) play crucial roles in various biological processes. Deep learning-based methods have been demonstrated powerful on predicting RBP sites on RNAs. However, the training of deep learni...

    **aoyong Pan, Yi Fang, **anfeng Li, Yang Yang, Hong-Bin Shen in BMC Genomics (2020)

  3. Article

    Open Access

    Prediction of RNA-protein sequence and structure binding preferences using deep convolutional and recurrent neural networks

    RNA regulation is significantly dependent on its binding protein partner, known as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs are still not well characterized. Interd...

    **aoyong Pan, Peter Rijnbeek, Junchi Yan, Hong-Bin Shen in BMC Genomics (2018)

  4. Article

    Open Access

    RNA-protein binding motifs mining with a new hybrid deep learning based cross-domain knowledge integration approach

    RNAs play key roles in cells through the interactions with proteins known as the RNA-binding proteins (RBP) and their binding motifs enable crucial understanding of the post-transcriptional regulation of RNAs....

    **aoyong Pan, Hong-Bin Shen in BMC Bioinformatics (2017)

  5. Article

    Open Access

    IPMiner: hidden ncRNA-protein interaction sequential pattern mining with stacked autoencoder for accurate computational prediction

    Non-coding RNAs (ncRNAs) play crucial roles in many biological processes, such as post-transcription of gene regulation. ncRNAs mainly function through interaction with RNA binding proteins (RBPs). To understa...

    **aoyong Pan, Yong-**an Fan, Junchi Yan, Hong-Bin Shen in BMC Genomics (2016)