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Article
Open AccessDisrupted gut microecology after high-dose 131I therapy and radioprotective effects of arachidonic acid supplementation
Despite the potential radiotoxicity in differentiated thyroid cancer (DTC) patients with high-dose 131I therapy, the alterations and regulatory mechanisms dependent on intestinal microecology remain poorly unders...
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Article
Open AccessExpression profile of long noncoding RNAs and comprehensive analysis of lncRNA-cisTF-DGE regulation in condyloma acuminatum
To identify differentially expressed long noncoding RNAs (lncRNAs) in condyloma acuminatum (CA) and to explore their probable regulatory mechanisms by establishing coexpression networks.
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Article
Open AccessCoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels
Genetic testing is crucial for precision cancer medicine. However, detecting multiple same-site insertions or deletions (indels) is challenging. Here, we introduce CoHIT (Cas12a-based One-for-all High-speed Is...
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Article
Research on the spatial pattern distribution of soil selenium using machine learning methods integrating geographic proximity in complex terrain
Selenium is an essential trace element that offers various health benefits. However, its uneven distribution results in selenium deficiency in many regions. Here, we aimed to investigate the influence of envir...
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Article
Open AccessIsolation and Identification of Postharvest Rot Pathogens in Citrus × tangelo and Their Potential Inhibition with Acidic Electrolyzed Water
This study focused on the identification of rot-causing fungi in Citrus × tangelo (tangelo) with a particular emphasis on investigating the inhibitory effects of acidic electrolyzed water on the identified pathog...
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Article
Covalent targeted radioligands potentiate radionuclide therapy
Targeted radionuclide therapy, in which radiopharmaceuticals deliver potent radionuclides to tumours for localized irradiation, has addressed unmet clinical needs and improved outcomes for patients with cancer1–4
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Article
The role of targeted therapy and/or immunotherapy therapy in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a highly invasive malignant tumor with a poor prognosis. Traditional treatment methods have not been effective. However, advancements in targeted therapy and immunotherapy...
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Article
Open AccessEquivariant score-based generative diffusion framework for 3D molecules
Molecular biology is crucial for drug discovery, protein design, and human health. Due to the vastness of the drug-like chemical space, depending on biomedical experts to manually design molecules is exceeding...
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Article
Enhanced Storage Resistance of Mulberries Using Laminated Cellulose Nanocrystals/Chitosan Composite Coatings
Fresh mulberry is a soft and juicy fruit with no protective layer on the skin, limiting its storage and transportation. Nanocellulose (NCC) and chitosan (CS) films have extensive potential in packaging due to ...
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Article
Open AccessPrevalence trends of anemia impairment in adolescents and young adults with HIV/AIDS
Anemia is a common complication of HIV/AIDS, particularly in adolescents and young adults across various countries and regions. However, little is known about the changing prevalence trends of anemia impairmen...
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Article
Extent of surgery for unilateral papillary thyroid cancer with nonsuspicious contralateral nodules by ultrasound
The discussion about surgical treatment of patients with papillary thyroid cancer(PTC) has been an ongoing issue, which is mainly focused on characteristics of tumor, but rarely on nonsuspicious contralateral ...
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Article
CT-based quantification of trachea shape to detect invasion by thyroid cancer
This study aims to develop a CT-based method for quantifying tracheal shape and evaluating its ability to distinguish between cases with or without tracheal invasion in patients with thyroid carcinoma.
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Article
Microbial Remediation of Crude Oil in Saline Conditions by Oil-Degrading Bacterium Priestia megaterium FDU301
Salinity greatly affects the microbial degradation process of crude oil; thus, the isolation and identification of halotolerant microbes is essential. Limited studies explored how microbes respond to increased...
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Open AccessKnockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
We aimed to screen novel gene signatures for ovarian cancer (OC) and explore the role of biomarkers in OC via regulating pyroptosis using bioinformatics analysis.
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Article
High-throughput DNA sequencing identifies population genetic structure and signatures of local adaptation in invasive populations of Spartina alterniflora in China
Understanding the ecological and evolutionary processes of invasive plants is a major goal in ecology. Invasive plant species often exhibit intraspecific phenotypic clines along geographic and climatic gradien...
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Article
Open AccessCo-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form during transcription and may be attributed to genomic stabili...
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Article
Open AccessPermuteDDS: a permutable feature fusion network for drug-drug synergy prediction
Drug combination therapies have shown promise in clinical cancer treatments. However, it is hard to experimentally identify all drug combinations for synergistic interaction even with high-throughput screening...
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Article
Fabrication and optical properties of mesoporous ZnSe nanosheets@SiO2 nanocomposites
Generally, the combination of semiconductor nanomaterials and an inert matrix could form a new material with enhanced optical property and corrosion resistance. Herein, 2D mesoporous sheet-like ZnSe nanostruct...
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Article
Open AccessSerum metabolism alteration behind different etiology, diagnosis, and prognosis of disorders of consciousness
Patients with disorders of consciousness (DoC) exhibit varied revival outcomes based on different etiologies and diagnoses, the mechanisms of which remain largely unknown. The fluctuating clinical presentation...
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Article
Open AccessMiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus
Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the...
