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Open AccessPatients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma
TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare but highly heterogeneous renal cell carcinoma (RCC) entity, of which the clinical treatment landscape is largely undefined. This study aims to evaluate a...
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Article
Open AccessHidden orders and phase transitions for the fully packed quantum loop model on the triangular lattice
Quantum loop and dimer models are prototypical correlated systems with local constraints, which are not only intimately connected to lattice gauge theories and topological orders but are also widely applicable...
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Open AccessHealth impacts of lifestyle and ambient air pollution patterns on all-cause mortality: a UK Biobank cohort study
Extensive evidence indicates that both lifestyle factors and air pollution are strongly associated with all-cause mortality. However, little studies in this field have integrated these two factors in order to ...
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Open AccessA step-by-step guide to causal study design using real-world data
Due to the need for generalizable and rapidly delivered evidence to inform healthcare decision-making, real-world data have grown increasingly important to answer causal questions. However, causal inference us...
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Open AccessReal-world performance of HIV low viral load values in diagnosing acute HIV infection in a tertiary care hospital in Bei**g, China
Early diagnosis of HIV infection decreases the time from HIV diagnosis to viral suppression and reduces further HIV transmission. The Chinese Guidelines for the Diagnosis and Treatment of HIV/AIDS (2021 editio...
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Open AccessAssociation of leukocyte telomere length with risk of all-cause and cardiovascular mortality in middle-aged and older individuals without cardiovascular disease: a prospective cohort study of NHANES 1999–2002
Leukocyte telomere length (LTL) shorting was significantly associated with mortality. This study aimed to investigate the potential association between LTL and all-cause mortality as well as cardiovascular dis...
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Open AccessEffectiveness of exercise rehabilitation on aplastic anemia patients receiving hematopoietic stem cell transplantation: study protocol for a randomized controlled trial
Although hematopoietic stem cell transplantation provides the chances of survival for aplastic anemia patients, it is also related to many treatment-related physical and psychological side effects that severel...
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Open AccessA novel score for predicting falls in community-dwelling older people: a derivation and validation study
Early detection of patients at risk of falling is crucial. This study was designed to develop and internally validate a novel risk score to classify patients at risk of falls.
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Open AccessThe DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia
The long-term maintenance of leukaemia stem cells (LSCs) is responsible for the high degree of malignancy in MLL (mixed-lineage leukaemia) rearranged acute myeloid leukaemia (AML). The DNA damage response (DDR) a...
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Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
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Open AccessRole of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis
Psoriasis vulgaris (PV) and Atopic dermatitis (AD) are the two major types of immune-mediated inflammatory skin disease (IMISD). Limited studies reported the association between Ubiquitin-conjugating enzyme E2...
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Correction to: Research progress of ferroptosis and inflammatory bowel disease
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Open AccessEffects of esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: a randomized controlled trial
Despite the implementation of various postoperative management strategies, the prevalence of postoperative fatigue syndrome (POFS) remains considerable among individuals undergoing laparoscopic radical gastrec...
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Article
Open AccessDEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...
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Open AccessThe 8th AJCC classification is inferior to a new neck stage based on intraparotid lymph node in parotid gland cancer
Lymph node (LN) status is an important prognostic factor for parotid gland cancer (PGC). This study aimed to analyze the impact of extranodal extension (ENE) of intraparotid LN and LN metastasis burden on surv...
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Open AccessEngineering of the complementary mutation site in tobacco mosaic virus p126 to develop a stable attenuated mutant for cross-protection
Tobacco mosaic virus (TMV; genus Tobamovirus) is one of the most prevailing pathogens that seriously affects the quality and yield of tobacco (Nicotiana tabacum) leaves. Cross-protection using mild strains is a p...
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Open AccessUnstructured Road Extraction in UAV Images based on Lightweight Model
There is no unified planning standard for unstructured roads, and the morphological structures of these roads are complex and varied. It is important to maintain a balance between accuracy and speed for unstru...
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Article
Open AccessMycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine
Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying mechanism remains unknown. Here, ...
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Article
Open AccessDevelopment of a machine learning-based model to predict prognosis of alpha-fetoprotein-positive hepatocellular carcinoma
Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with ...
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Open AccessFlash heating process for efficient meat preservation
Maintaining food safety and quality is critical for public health and food security. Conventional food preservation methods, such as pasteurization and dehydration, often change the overall organoleptic qualit...
