8 Result(s)
within
**aoxiao Sun
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
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Article
Transcriptional regulation of autophagy by an FXR–CREB axis
The FXR–CREB axis is identified as a key physiological switch that regulates autophagy during feeding/fasting cycles; in the fed state, the nuclear receptor FXR is shown to suppress autophagy in the liver by i...
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Article
Open AccessInteractions and exchange of CO2 and H2O in coals: an investigation by low-field NMR relaxation
The mechanisms by which CO2 and water interact in coal remain unclear and these are key questions for understanding ECBM processes and defining the long-term behaviour of injected CO2. In our experiments, we inje...
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Article
Open AccessAn epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to...
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Article
Open AccessEnsemble dimensionality reduction and feature gene extraction for single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) technologies allow researchers to uncover the biological states of a single cell at high resolution. For computational efficiency and easy visualization, dimensionality r...
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Article
Open AccessAngiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health and policy. However, which signals function as a nexus to tra...
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Article
Open AccessNeurophysiological markers of emotion regulation predict efficacy of entrepreneurship education
Recent evidence shows that programs targeting the socio-emotional dimensions of entrepreneurship—e.g., resilience, personal initiative, and empathy—are more highly correlated with success along with key busine...
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Article
Open AccessA non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent stud...
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Article
Open AccessA negative feedback loop between TET2 and leptin in adipocyte regulates body weight
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, functioning as an essential epigenetic regul...
