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Article
Computational modeling and simulation of bioinspired nacre-like composites
Inspired by design motifs driving the balanced combination of rigidity, strength, and toughness in biological materials, this paper presents 3D computational modeling and simulation of an interface-enriched hy...
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Article
Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy
In order to enhance the therapeutic effect of chemotherapy on liver cancer, a biodegradable formulation of protamine-modified paclitaxel-loaded poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co
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Article
Open AccessSurface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapy
The efficient delivery of therapeutic genes into cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, a novel TPGS-b-(PCL-ran-PGA) nanoparticle modified wi...
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Article
Modeling and Simulation of Soft Contact and Adhesion of Stem Cells
In this paper, we briefly report our recent work on multiscale modeling and simulations of soft elasticity and focal adhesion of stem cells. In particular, our work is focused on modeling and simulation of con...
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Article
Open AccessOral Delivery of DMAB-Modified Docetaxel-Loaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy
Three types of nanoparticle formulation from biodegradable PLGA-TPGS random copolymer were developed in this research for oral administration of anticancer drugs, which include DMAB-modified PLGA nanoparticles...