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Article
Study on the Influence of Grouting Treatment on the Movement and Deformation of Surface in Longwall Coal Mining Goaf Areas
The grouting treatment of the old goaf in a coal mine is an essential measure to ensure the safety of the road above it. A novel calculation model is proposed to more accurately determine the appropriate treat...
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Article
The broken-exponential radial structure and larger size of the Milky Way galaxy
The radial structure of a galaxy is a fundamental property that reflects its growth and assembly history. Although it is straightforward to measure that of external galaxies, it is challenging for the Milky Wa...
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Article
Open AccessExperimental investigation of the influence of mine water on mechanical properties of resin grout
Resin grout is widely used in geotechnical and underground engineering, and is often affected by different mine water solutions. This study considered the effects of different mine water solutions and soaking ...
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Article
Degradation of organic pollutants by the Cl−/PMS process
The viewpoints on whether high concentrations of chloride ion (Cl−) promote or inhibit the oxidation activity of activated persulfates are still inconclusive. Furthermore, the degradation of organic pollutants by...
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Article
Open AccessSubthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy
The subthalamic nucleus (STN) is pivotal in basal ganglia function in health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson’s patients undergoing deep brain stimulation (...
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Article
Enhanced K-NN with Bayesian optimization algorithm for predicting energy efficiency of smart grids in IoT
With the increasing a huge amount of end users using electricity in modern cities, smart grids have some critical problems for energy efficiency and managing renewable energy resources. Therefore, electricity ...
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Article
Investigation of the Causal Relationship Between Autoimmune Diseases and Premature Ovarian Insufficiency
POI is a multifactorial disease due to lack of estrogen resulting in symptoms such as insomnia, osteoporosis, and voiding disorders. For most women, fertility is affected. Autoimmune diseases are chronic disea...
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Article
Cervical elastography: finding a novel predictor for improving the prediction of preterm birth in uncomplicated twin pregnancies
This study set out to investigate a novel ultrasound parameter using cervical elastosonography for improving the prediction of spontaneous preterm birth (sPTB) in twin pregnancies.
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Article
Open AccessHyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease
Dysbiosis of the gut microbiota is pivotal in Crohn’s disease (CD) and modulated by host physiological conditions. Hyperbaric oxygen therapy (HBOT) is a promising treatment for CD that can regulate gut microbi...
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Article
Open AccessThe cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis
The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction of CD8+ T cells. Continuous antigen stimulation disrupts the expansion, effector function, and metabo...
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Article
Open AccessIdentification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification
Despite the extensive study of MYCN-amplified neuroblastomas, there is a significant unmet clinical need in MYCN non-amplified cases. In particular, the extent of heterogeneity within the MYCN non-amplified popul...
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Article
On-device phase engineering
In situ tailoring of two-dimensional materials’ phases under external stimulus facilitates the manipulation of their properties for electronic, quantum and energy applications. However, current methods are mai...
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Article
Effects of bedding plane properties on mechanical, acoustic emission and micro failure characteristics of bedded rock mass
To study the effects of bedding plane properties on the mechanical, acoustic emission and micro failure characteristics of bedded rock mass, uniaxial compression tests of bedded rock mass with different beddin...
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Article
Open AccessStudy of association of leptin with leukocyte telomere length in a Chinese rural population
Previous studies have demonstrated the relationship between adipocyte factors, insulin resistance, and other indicators with telomere length. However, these studies did not consider the influence of changes in...
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Article
Open AccessEngineering an artificial catch bond using mechanical anisotropy
Catch bonds are a rare class of protein-protein interactions where the bond lifetime increases under an external pulling force. Here, we report how modification of anchor geometry generates catch bonding behav...
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Article
Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model
Scale effects play critical roles in the mechanical responses of microstructures. An isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded microbeam...
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Article
Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical sequelae. Resveratrol (Res) has pharmacological effects in the treatment of RA, but it has...
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Article
A graph-optimized deep learning framework for recognition of Barrett’s esophagus and reflux esophagitis
Barrett’s esophagus (BE) recognition is essential for the diagnosis of esophageal adenocarcinoma (EAC), a highly fatal disease when left untreated at earlier stages of cancer development. General endoscopists ...
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Article
Machine learning framework develops neutrophil extracellular traps model for clinical outcome and immunotherapy response in lung adenocarcinoma
Neutrophil extracellular traps (NETs) are novel inflammatory cell death in neutrophils. Emerging studies demonstrated NETs contributed to cancer progression and metastases in multiple ways. This study intends ...
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Article
Elevated CO2 leads to thick-skinned thrips by altering trehalose and chitin metabolisms
Elevated CO2 (eCO2) can affect the environmental adaptability of herbivorous insects by affecting the quality and quantity of host plants’ nutrients under climate change. In this study, the impacts of eCO2 on car...
