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Article
Open AccessGynostemma Pentaphyllum ameliorates CCl4-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics
Gynostemma pentaphyllum (Thunb.) Makino, commonly known as “southern ginseng”, contains high amounts of ginsenoside derivatives and exhibits similar biological activities with Panax ginseng (C. A. MEY) (ginseng),...
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Article
Open AccessAssociation between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease
It is unclear whether short-term blood pressure variability (BPV) is associated with target organ damage in patients with non-dialysis chronic kidney disease (CKD).
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Article
Open AccessShared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome
There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins inc...
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Article
Open AccessNon-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development
Fine-map** and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA...
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Article
Open AccessUltrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections
Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor b...
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Article
Site-specific reactivity of stepped Pt surfaces driven by stress release
Heterogeneous catalysts are widely used to promote chemical reactions. Although it is known that chemical reactions usually happen on catalyst surfaces, only specific surface sites have high catalytic activity...
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Article
Open AccessThe clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study
Serum tumor markers (STM), extensively used for the diagnosis, monitoring and prognostic assessment of tumors, can be increased in some non-malignant lung diseases. To date, there is a paucity of studies regar...
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Article
A review of solid-state lithium metal batteries through in-situ solidification
High-energy-density lithium metal batteries are the next-generation battery systems of choice, and replacing the flammable liquid electrolyte with a polymer solid-state electrolyte is a prominent conduct towar...
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Chapter and Conference Paper
Conditional Value at Risk Model of New Power System Reserve Assessment Considering Primary Energy Supply Risk
To deal with the difficulty of assessing the reserve demand of the new power system caused by the strong randomness in the new power system, a reserve assessment method of the new power system considering the ...
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Article
Open AccessSexual violence among male sexual minority college students in Guangdong, China: a cross-sectional study
This study aims to provide an estimate of lifetime sexual violence (SV) among male sexual minority college students with differing sexual orientations and contribute to the evidence base on the association bet...
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Article
Improved Efficient Synthesis of the Transthyretin Amyloid Fibril Inhibitor Tafamidis
Aconvenient and efficient route for the preparation of Tafamidis, the first and only medicine for patients with either wild-type or hereditary ATTR-CM so far, has been developed in 91% total yield over four st...
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Article
Automatic trajectory generation for metal surface droplet coloring
In this study, an automatic trajectory-generation algorithm is proposed to achieve uniform droplet coloring on the metal surfaces. First, by taking into account key parameters such as contact angle, surface te...
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Article
Open AccessA functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
Preterm birth (PTB), defined as delivery before 37 gestational weeks, imposes significant public health burdens. A recent maternal genome-wide association study of spontaneous PTB identified a noncoding locus ...
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Article
Open AccessMETTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b
Methyltransferase-like 3 (METTL3), a key member of the m6A methyltransferase complex, is upregulated in multiple human malignancies and plays a role in regulating tumor migration. This study aimed to reveal th...
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Article
Inflammation responsive tofacitinib loaded albumin nanomedicine for targeted synergistic therapy in ulcerative colitis
Patients with ulcerative colitis (UC) often loss responses over long term usage of conventional therapies. Tofacitinib, a pan-Janus kinases (JAK) inhibitor is approved for moderate to severe UC treatment, whil...
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Article
Open AccessNOMe-HiC: joint profiling of genetic variant, DNA methylation, chromatin accessibility, and 3D genome in the same DNA molecule
Cis-regulatory elements are coordinated to regulate the expression of their targeted genes. However, the joint measurement of cis-regulatory elements’ activities and their interactions in spatial proximity is ...
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Article
ATP9A knockdown leads to neurite fracture and retraction
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Article
ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity
ATP9A, a lipid flippase of the class II P4-ATPases, is involved in cellular vesicle trafficking. Its homozygous variants are linked to neurodevelopmental disorders in humans. However, its physiological functio...
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Article
Open AccessAutophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review
The major active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is known for its wide bioactivity in periodontal tissues. Although the exact mechanisms underlying its protective action against periodont...
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Article
Open AccessRelationship between diet-related inflammation and bone health under different levels of body mass index
Osteoporosis is a major public health problem. Dietary inflammatory preference and body mass index (BMI) are emerging factors that tends to affect bone health. There is limited evidence regarding the joint inf...
