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Article
Open AccessMYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration
Metabolic remodeling is a strategy for tumor survival under stress. However, the molecular mechanisms during the metabolic remodeling of colorectal cancer (CRC) remain unclear. Melanocyte proliferating gene 1 ...
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Article
Machine Learning Exploration of the Relationship Between Drugs and the Blood–Brain Barrier: Guiding Molecular Modification
This study aimed to improve the efficiency of pharmacotherapy for CNS diseases by optimizing the ability of drug molecules to penetrate the Blood-Brain Barrier (BBB).
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Article
Novel use of sugarcane leaf polysaccharide in κ-carrageenan blend hydrogel
Sugarcane leaves are the abundant crop residues on the field after sugarcane harvesting. This study was designed to investigate the effect of sugarcane leaf polysaccharide on the chemical, physicochemical, and...
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Article
Tenascin-C promotes the proliferation and fibrosis of mesangial cells in diabetic nephropathy through the β-catenin pathway
To mechanistically assess the involvement of tenascin-C (TNC) in diabetic nephropathy (DN).
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Open AccessExploring the potential use of Chinese herbs in regulating the inflammatory microenvironment of tumours based on the concept of ‘state-target identification and treatment’: a scoo** review
Tumours do not exist in isolation from the organism; their growth, proliferation, motility, and immunosuppressive response are intricately connected to the tumour’s microenvironment. As tumour cells and the mi...
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Open AccessTubular basement membrane deposits after allogeneic hematopoietic stem cell transplantation
Extraglomerular immune complex deposition is rare and only a few membranous nephropathy cases with tubular basement membrane deposits have been reported following allogeneic hematopoietic stem cell transplanta...
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Article
The significance of galactose-deficient immunoglobulin A1 staining in kidney diseases with IgA deposition
This study investigated the significance of galactose-deficient immunoglobulin A1 staining in kidney diseases with IgA deposition.
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Lessons for the clinical nephrologist: a case of noncrystalline light chain proximal tubulopathy
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Existence and Uniqueness of Local Weak Solution of D-Dimensional Fractional Micropolar Rayleigh-Bénard Convection System Without Thermal Diffusion in Besov Space
This paper studies the existence and uniqueness of local weak solutions to the d-dimensional ( d ≥ ...
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Article
Open AccessCombined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model
Inflammatory bowel diseases, consisting of Crohn’s disease and ulcerative colitis constitute chronic inflammatory conditions that may compromise the whole gastrointestinal tract as well as the colonic mucosa. ...
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Open AccessHuman kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection
It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a retrospective analysis of clin...
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Open AccessComprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database
Yiganmingmu oral liquid (YGMM), a well known over-the-counter (OTC) drug in China, is composed of 12 types of valuable herbal medicines and has been widely used in clinical for the treatment of soreness and we...
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Article
Effect of cinnamon bark and twig extracts on the chemical, physicochemical and antioxidant properties of fermented milk
This study was conducted to investigate the effect of cinnamon bark (CB) and twig (CT) extracts on the chemical (total phenolics (TPC), flavonoids (TFC), sugars content), physicochemical (pH, total acidity, sh...
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Article
Polysaccharide extraction from sugarcane leaves: combined effects of different cellulolytic pretreatment and extraction methods
This research was conducted to determine the combined effects of different cellulolytic pretreatments (cellulase vs. mixed enzymes) and extraction methods (water vs. deep eutectic solvent, DES) on the yield, c...
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Article
Bioactivity-based antioxidative components screening and evaluation in grape seed proanthocyanidin extract
Grape seed proanthocyanidin extract (GSPE), a type of functional food, possesses potent antioxidant activity. In this study, GSPE protected human embryonic kidney 293 (HEK 293) cells from H2O2-induced cell injury...
