13 Result(s)
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Open AccessAuthor Correction: Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury
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Open AccessAuthor Correction: Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
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Open AccessPorous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation. However, efficient delive...
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Open AccessIntegrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion
Rodent dorsal root ganglion (DRG) is widely used for studying axonal injury. Extensive studies have explored genome-wide profiles on rodent DRGs under peripheral nerve insults. However, systematic integration ...
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Molecular landscapes of human hippocampal immature neurons across lifespan
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents1,2 and are dysregulated in multiple human neurological disorders3–
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Open AccessComparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice
Peripheral nerve injury impairs motor and sensory function in humans, and its functional recovery largely depends on the axonal outgrowth required for the accurate reinnervation of appropriate targets. To bett...
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Open AccessTubulation repair mitigates misdirection of regenerating motor axons across a sciatic nerve gap in rats
The repair of peripheral nerve laceration injury to obtain optimal function recovery remains a big challenge in the clinic. Misdirection of regenerating axons to inappropriate target, as a result of forced mis...
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Open AccessRegulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury
Peripheral nerve injury is a global problem that causes disability and severe socioeconomic burden. Brain-derived neurotrophic factor (BDNF) benefits peripheral nerve regeneration and becomes a promising thera...
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Open AccessReactive oxygen species generated from skeletal muscles are required for gecko tail regeneration
Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS functions on spontaneous tail regeneration ...
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Open AccessGekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration
Reptiles are the most morphologically and physiologically diverse tetrapods, and have undergone 300 million years of adaptive evolution. Within the reptilian tetrapods, geckos possess several interesting featu...
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Open AccessThe transcriptional landscape of dorsal root ganglia after sciatic nerve transection
Following peripheral nerve injury, transcriptional responses are orchestrated to regulate the expression of numerous genes in the lesioned nerve, thus activating the intrinsic regeneration program. To better u...
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Open AccessCD59 mediates cartilage patterning during spontaneous tail regeneration
The regeneration-competent adult animals have ability to regenerate their lost complex appendages with a near-perfect replica, owing to the positional identity acquired by the progenitor cells in the blastema,...
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Open AccessTruncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease
Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a primary tau kinase that is most imp...
