28 Result(s)
within
**aosong Gu
Cell Biology
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Article
Increased gene expression of β-1,4-galactosyltransferase I in rat injured sciatic nerve
During neurite outgrowth on basal lamina, cell-surface β-1,4-galactosyltransferase I (β-1,4-GalT-I) functions as one of the receptors of laminin by binding to N-linked oligosaccharides on the laminin E8 domain. I...
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EST-based identification of genes expressed in brain and spinal cord of Gekko japonicus, a species demonstrating intrinsic capacity of spinal cord regeneration
In the present study, a brain and spinal cord cDNA library of Gekko japonicus was constructed, and 2349 unique expressed sequence tags (ESTs), composed of 494 clusters and 1855 singletons, were determined from 41...
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Article
Expression of myostatin RNA transcript and protein in gastrocnemius muscle of rats after sciatic nerve resection
Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, has been identified as an inhibitor of skeletal muscle mass. To have an insight into the expression pattern of myostatin and its pot...
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Article
Investigation of differentially expressed proteins in rat gastrocnemius muscle during denervation–reinnervation
To have a better insight into the molecular events involved in denervation-induced atrophy and reinnervation-induced regeneration of skeletal muscles, it is important to investigate the changes in expression l...
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Article
Tpc1808 increases expression of NF-H in PC12 cells
Tpc1808 is a candidate chemotropic factor induced by nerve injury, and we report here the role of rat Tpc1808 in the expression of high-molecular-weight neurofilament (NF-H) in PC12 cells...
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Article
Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro
Bone marrow stromal cells (MSCs) have the capability of differentiating into mesenchymal and non-mesenchymal lineages. In this study, MSCs isolated from adult Sprague-Dawley rats were cultured to proliferation...
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Article
Neuroprotective Effects of Salidroside in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation
The hypoglycemia and serum limitation-induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders. Salidroside is a phenylpropan...
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The Molecular Cloning of Platelet-Derived Growth Factor-C (PDGF-C) Gene of Gekko japonicus and Its Expression Change in the Spinal Cord After Tail Amputation
The platelet-derived growth factor-C (PDGF-C) gene of Gekko japonicus was obtained from a brain and spinal cord cDNA library. The results of Northern blot showed that transcript of PDGF-C gene of gecko is 2.8 kb ...
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Article
Effects of Bone Marrow Stromal Cell-conditioned Medium on Primary Cultures of Peripheral Nerve Tissues and Cells
Implantation of bone marrow stromal cells (MSCs) produces an improved functional outcome of peripheral nerve repair. In this study, rat dorsal root ganglion (DRG) explants, rat DRG neurons, and rat Schwann cel...
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Article
Molecular cloning and expression of visinin-like protein 1 from Gekko japonicus spinal cord
Visinin-like protein 1 (VILIP-1), a myristoylated calcium sensor protein of the EF-hand Ca2+-binding protein superfamily, plays multiple physiological roles in the central nervous system and peripheral organs. In...
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Article
Neurotrophic Actions of Bone Marrow Stromal Cells on Primary Culture of Dorsal Root Ganglion Tissues and Neurons
Application of adult bone marrow stromal cells (BMSCs) provides therapeutic benefits to the treatment of neurological insults. The aim of this study was to explore the potential of nonhematopoietic BMSCs to pr...
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Article
The molecular cloning of glial fibrillary acidic protein in Gekko japonicus and its expression changes after spinal cord transection
The glial fibrillary acidic protein (GFAP) is an astrocyte-specific member of the class III intermediate filament proteins. It is generally used as a specific marker of astrocytes in the central nervous system...
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Article
Glioma Stem/Progenitor Cells Contribute to Neovascularization via Transdifferentiation
Previous studies suggest that tumor cells might be the progenitor for tumor vasculature. Whether vascular tube formation from transdifferentiation of human glioma stem/progenitor cells (hGSPCs) contribute to a...
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Article
The expression changes of Numblike in rat brain cortex after traumatic brain injury
Numblike (Numbl) plays an important role in ependymal wall integrity and subventricular zone neuroblast survival. And Numbl is specifically expressed in the brain. However, its expression and function in the c...
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Article
Early neurogenesis during caudal spinal cord regeneration in adult Gekko japonicus
Gekko japonicus undergoes dramatic changes in the caudal spinal cord after tail amputation. The amputation induces cell proliferation in the caudal ependymal tube. We performed hematoxylin and eo...
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Article
Cyclic AMP-Dependent Protein Kinase Enhances SC35-Promoted Tau Exon 10 Inclusion
Alternative splicing of tau exon 10 generates tau with three or four microtubule-binding repeats (3R-tau or 4R-tau). The ratio of 3R-tau to 4R-tau is approximately 1:1 in the adult normal human brain. Disturba...
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Article
Basic Fibroblast Growth Factor (bFGF) Facilitates Differentiation of Adult Dorsal Root Ganglia-Derived Neural Stem Cells Toward Schwann Cells by Binding to FGFR-1 Through MAPK/ERK Activation
Considerable research has been devoted to unraveling the regulation of neural stem cell (NSC) differentiation. The responses of NSCs to various differentiation-inducing stimuli, however, are still difficult to...
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The Regenerating Spinal Cord of Gecko Maintains Unaltered Expression of β-Catenin Following Tail Amputation
The Wingless/Integrated (Wnt) signaling pathway plays important roles in central nervous system (CNS) development and regeneration, and β-catenin, the central component, has been considered in association with...
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Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a/FOXO1 Axis
Natural polysaccharides are biomaterials widely used for constructing scaffolds in tissue engineering. While natural polysaccharides have been shown to robustly promote tissue regeneration, the underlying mole...
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Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3
Following peripheral nerve injury, hypoxia is formed as a result of defects in blood supply at the injury site. Despite accumulating evidence on the effects of microRNAs (miRNAs) on phenotype modulation of Sch...
