145 Result(s)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

The association between pregnancy levels of blood lipids and the risk of preterm birth

Preterm labor, a condition associated with various risk factors such as a history of prior preterm birth (PTB) and multiple pregnancies, has recently seen an increasing focus on its potential link with dyslipi...

Yao Lv, Liang Xu, Zhong He, **aorui Liu, Yuna Guo in Scientific Reports (2024)

Article

A multi-omics analysis-based model to predict the prognosis of low-grade gliomas

Lower-grade gliomas (LGGs) exhibit highly variable clinical behaviors, while classic histology characteristics cannot accurately reflect the authentic biological behaviors, clinical outcomes, and prognosis of ...

Zhijie Du, Yuehui Jiang, Yueling Yang, **aoyu Kang, **g Yan… in Scientific Reports (2024)

Article

Inter- and trans-generational impacts of real-world PM_2.5 exposure on male-specific primary hypogonadism

Exposure to PM_2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...

**aoyu Wei, Zhonghao Zhang, Yayun Gu, Rong Zhang, Jie Huang, Feng Li… in Cell Discovery (2024)

Article

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically describ...

Liang Chen, Haotong Li, **aorui Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy

Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lip...

Hanbing Wang, **n Zhang, Yipeng Zhang, Tao Shi, Yue Zhang, Xueru Song… in BMC Cancer (2024)

Article

In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response

Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive micr...

Qin Liu, Rui Xu, **gwen Shen, Ya** Tao, **gyi Shao… in Journal of Translational Medicine (2024)

Article

Predictive value of peripheral blood biomarkers in patients with non-small-cell lung cancer responding to anti-PD-1-based treatment

The introduction of the anti-PD-1 antibody has greatly improved the clinical outcomes of patients with non-small cell lung cancer (NSCLC). In this study, we retrospectively analyzed the efficacy of PD-1 antibo...

Shu Su, Fungjun Chen, **n Lv, Liang Qi, Zhou Ding… in Cancer Immunology, Immunotherapy (2024)

Article

Umbrella strategy with systemic and intraperitoneal chemotherapy versus systemic chemotherapy in patients with advanced gastric cancer: a multicenter, randomized Phase III clinical trial

We have developed a tridirectional regimen combining intraperitoneal, intravenous, and oral chemotherapy as a treatment for patients with advanced gastric cancer and individualized these chemotherapeutics acco...

Yang Yang, Jia Wei, Juan Du, Zhengyun Zou, Rongfu Wei… in Clinical Cancer Bulletin (2023)

Article

Correction: Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer

Jie Mei, Leiyu Hao, **aorui Liu, Guangshun Sun, Rui Xu, Huiyu Wang… in Biomarker Research (2023)

Article

First report of powdery mildew on Pugionium cornutum (L.) Gaertn caused by Erysiphe cruciferarum in China

**uxia Bao, Chongyi Fu, Yong Lian, **aorui Liu, Yan Liu… in Journal of Plant Pathology (2023)

Article

Expression of four cancer-testis antigens in TNBC indicating potential universal immunotherapeutic targets

Immunotherapy is an attractive treatment for breast cancer. Cancer-testis antigens (CTAs) are potential targets for immunotherapy for their restricted expression. Here, we investigate the expression of CTAs in...

Jie **ao, Fengli Huang, Lin Li, Lianru Zhang… in Journal of Cancer Research and Clinical On… (2023)

Article

Associations of adverse childhood experiences with common psychiatric disorder in later life: results from the China mental health survey

Associations between adverse childhood experiences (ACEs) and common psychiatric disorders among older Chinese individuals have not been well reported. The objectives of this study are to examine the prevalenc...

**hao Li, Zhaorui Liu, Minghui Li, Yueqin Huang, Huifang Yin… in BMC Geriatrics (2023)

Article

Costs and health benefits of the rural energy transition to carbon neutrality in China

The rural energy transition is critical in China’s efforts to achieve carbon neutrality and improve air quality. However, the costs and health benefits associated with the transition to carbon neutrality remai...

Teng Ma, Silu Zhang, Yilong **ao, **aorui Liu, Minghao Wang… in Nature Communications (2023)

Article

Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy

In situ tumor vaccine has been gradually becoming a hot research field for its advantage of achieving personalized tumor therapy without prior antigen identification. Various in situ tumor vaccine regimens hav...

Zhichen Sun, Yanhong Chu, Jie **ao, Yueling Yang… in Journal of Translational Medicine (2023)