-
Article
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is fuelled by studies showing that ageing tissues are often riddled with clones of complex oncogenic backgrounds coexisting...
-
Article
Open AccessSafeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Ensuring genome safety during gene editing is crucial for clinical translation of the high-efficient CRISPR-Cas9 toolbox. Therefore, the undesired events including chromosomal translocations, vector integratio...
-
Article
Open AccessRas drives malignancy through stem cell crosstalk with the microenvironment
Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy1–4. At tumour–stromal interfaces, a subset of tumour-initiating proge...
-
Article
Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
Adhesion G protein-coupled receptors are elusive in terms of their structural information and ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo-ADGRG2, an essential membrane...
-
Article
Open AccessCTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice
C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine secreted by adipose tissue, related to chondrocyte proliferation, inflammation, and glucose homeostasis. However, the therapeutic effects on ...
-
Article
Open AccessComprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Because of their small size, the recently developed CRISPR-Cas12f nucleases can be effectively packaged into adeno-associated viruses for gene therapy. However, a systematic evaluation of the editing outcomes ...
-
Article
Randomized Controlled Trial of Breast Nodule Lysis Versus Tamoxifen for the Treatment of Mammary Gland Hyperplasia
To study the efficacy of breast nodule lysis (BNL) for the treatment of mammary gland hyperplasia (MGH). A total of 304 patients with MGH and breast pain were randomly divided into a BNL group and an oral tamo...
-
Article
Structural insights into the activation of GLP-1R by a small molecule agonist
-
Article
Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine
The α2 adrenergic receptors (α2ARs) are G protein-coupled receptors (GPCRs) that respond to adrenaline and noradrenaline and couple to the Gi/o family of G proteins. α2ARs play important roles in regulating the s...
-
Article
Open AccessGdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice
The growth differentiation factor 11 (GDF11) was shown to reverse age-related hypertrophy on cardiomyocytes and considered as anti-aging rejuvenation factor. The role of GDF11 in regulating metabolic homeostas...
-
Article
Water-blocking nano-composite cement-based grouting materials
With the rapid development of underground engineering construction such as hydropower projects, mines, tunnels, etc., underground hydrodynamic-related problems have become a more prominent challenge. In view o...
-
Article
Low temperature green nano-composite vegetable-gum drilling fluid
Drilling in alpine ecological fragile areas for the energy and mineral exploration needs superior low temperature drilling fluids with the required environmental protection of the ecosystem and a high efficien...
-
Article
Open AccessA high-quality apple genome assembly reveals the association of a retrotransposon and red fruit colour
A complete and accurate genome sequence provides a fundamental tool for functional genomics and DNA-informed breeding. Here, we assemble a high-quality genome (contig N50 of 6.99 Mb) of the apple anther-derive...
-
Article
Open AccessAn improved yeast surface display platform for the screening of nanobody immune libraries
Fusions to the C-terminal end of the Aga2p mating adhesion of Saccharomyces cerevisiae have been used in many studies for the selection of affinity reagents by yeast display followed by flow cytometric analysis. ...
-
Article
Author Correction: Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
In Fig. 2g of this Article, a panel was inadvertently duplicated. The ‘D30 IMQ’ image was a duplicate of the ‘D6 Ctrl’ image. Fig. 2g has been corrected online to show the correct ‘D30 IMQ’ image (showing skin...
-
Article
Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy
Tumor endothelial marker 1 (TEM1) has been identified as a novel surface marker upregulated on the blood vessels and stroma in many solid tumors. We previously isolated a novel single-chain variable fragment (...
-
Article
Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury
Anisodamine protects against free radical-induced cellular damage. This study aimed to investigate the protective effect of anisodamine on rhabdomyolysis-induced acute kidney injury (RIAKI). C57BL/6 J mice, TXNIP
-
Article
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
The skin barrier is the body’s first line of defence against environmental assaults, and is maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory pressures, neither th...
-
Article
Open AccessBone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223
Recent studies have indicated that microRNA-223 (miR-223) plays a role in the tissue-protective effect of mesenchymal stem cells (MSCs). NLR family-pyrin domain containing 3 (NLRP3) was reported to affect a re...
-
Article
Open AccessCigarette Smoke-Induced Pulmonary Inflammation and Autophagy Are Attenuated in Ephx2-Deficient Mice
Cigarette smoke (CS) increases the risk of chronic obstructive pulmonary disease (COPD) by causing inflammation, emphysema, and reduced lung function. Additionally, CS can induce autophagy which contributes to...
