18 Result(s)

Article

Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics

Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers. The a...

**aohan Shi, Shiwei Guo, Qiaonan Duan… in Journal of Experimental & Clinical Cancer … (2024)

Article

Local resection via partial lamellar sclerouvectomy for ciliary body tumors — a case series

Ciliary body tumor is extremely rare and treatment is challenging. The aim of this study is to present our experience in treating this rare entity, especially large tumors with more than 5 clock hours of invol...

Ruonan Wang, Li Su, Hong Wang, Xuemei Zhang, Weijun Wang, Kun Liu… in BMC Ophthalmology (2024)

Article

Clinicopathological characteristics and prognosis of metaplastic breast cancer versus triple-negative invasive ductal carcinoma: a retrospective analysis

Metaplastic breast cancer(MBC) is a specific pathological type of invasive breast cancer. There are few studies related to MBC due to its rarity. This study aimed to analyse the differences in clinicopathologi...

**aolu Yang, Tiantian Tang, Tao Zhou in World Journal of Surgical Oncology (2023)

Article

Relationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis

To explore the relationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis (DCK).

Zihao Chai, **aolu Yang, Haitao Lu… in Journal of Orthopaedic Surgery and Research (2023)

Article

Author Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Yige Wu, Nadezhda V. Terekhanova, Wagma Caravan… in Nature Communications (2023)

Article

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34...

Yige Wu, Nadezhda V. Terekhanova, Wagma Caravan… in Nature Communications (2023)

Article

Ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma: a prospective study

This single-arm, prospective, exploratory study investigated the effectiveness of ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma (OAL).

**aolu Yang, Ruonan Wang, **aochun Yuan, Shengyu Yao, Chungang Wang… in Radiation Oncology (2022)

Article

Dietary exposure of radionuclides and heavy metals in adult residents in a high background natural radiation area using duplicate diet method

Intake of radionuclides and heavy metals through food consumption is one of the important pathways for long-term health considerations. In this paper, the dietary exposure to radionuclides (²¹⁰Pb, ²¹⁰Po, ²²⁶Ra, ^2...

Baolu Yang, Fei Tuo, Qiang Zhou, **g Zhang, Zeshu Li, Chaoya Pang in Scientific Reports (2022)

Article

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucle...

Daniel Cui Zhou, Reyka G. Jayasinghe, Siqi Chen, John M. Herndon… in Nature Genetics (2022)

Article

Divergent patterns of selection on metabolite levels and gene expression

Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes involved in ergosterol biosynthesis—an esse...

Alexander F. Kern, Grace **aolu Yang, Neil M. Khosla… in BMC Ecology and Evolution (2021)

Article

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER) homeostasis under adverse conditions, yet the underlying mechanisms are not well defined. Here, through the evaluation of all...

Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li… in Nature Communications (2020)

Article

KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis

Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How...

Tian Niu, Lu Cheng, Hanying Wang, Shaopin Zhu, **aolu Yang… in Journal of Neuroinflammation (2019)

Article

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes. Neat1 associates with the...

Pengfei Zhang, Limian Cao, Rongbin Zhou, **aolu Yang, Mian Wu in Nature Communications (2019)

Article

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p...

Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao… in Nature Communications (2018)

Article

TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14

The proteasome is a complex protease critical for protein quality control and cell regulation, and its dysfunction is associated with cancer and other diseases. However, the mechanisms that control proteasome ...

Liang Chen, Guixin Zhu, Eleanor M. Johns, **aolu Yang in Nature Communications (2018)

Article

Genetic variations in ARE1 mediate grain yield by modulating nitrogen utilization in rice

In crops, nitrogen directly determines productivity and biomass. However, the improvement of nitrogen utilization efficiency (NUE) is still a major challenge in modern agriculture. Here, we report the characte...

Qing Wang, **qiang Nian, **anzhi **e, Hong Yu, Jian Zhang… in Nature Communications (2018)

Article

Changes in Retinal Nerve Fiber Layer Thickness after Multiple Injections of Novel VEGF Decoy Receptor Conbercept for Various Retinal Diseases

Conbercept is a recombinant fusion protein with high affinity for all vascular endothelial growth factor isoforms and placental growth factor. The repeated intravitreal injection of conbercept may cause intrao...

Zhihua Zhang, **aolu Yang, Huiyi **, Yuan Qu, Yuan Zhang, Kun Liu… in Scientific Reports (2016)

Article

Apoptotic regulation and tRNA

Apoptotic regulation is critical to organismal homeostasis and protection against many human disease processes such as cancer. Significant research efforts over the past several decades have illuminated many s...

Yide Mei, Aaron Stonestrom, Ya-Ming Hou, **aolu Yang in Protein & Cell (2010)