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Open AccessDetection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics
Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers. The a...
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Open AccessLocal resection via partial lamellar sclerouvectomy for ciliary body tumors — a case series
Ciliary body tumor is extremely rare and treatment is challenging. The aim of this study is to present our experience in treating this rare entity, especially large tumors with more than 5 clock hours of invol...
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Open AccessClinicopathological characteristics and prognosis of metaplastic breast cancer versus triple-negative invasive ductal carcinoma: a retrospective analysis
Metaplastic breast cancer(MBC) is a specific pathological type of invasive breast cancer. There are few studies related to MBC due to its rarity. This study aimed to analyse the differences in clinicopathologi...
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Open AccessRelationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis
To explore the relationship between C2 slope with sagittal parameters and clinical function of degenerative cervical kyphosis (DCK).
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Open AccessAuthor Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
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Open AccessEpigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34...
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Open AccessUltra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma: a prospective study
This single-arm, prospective, exploratory study investigated the effectiveness of ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma (OAL).
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Open AccessDietary exposure of radionuclides and heavy metals in adult residents in a high background natural radiation area using duplicate diet method
Intake of radionuclides and heavy metals through food consumption is one of the important pathways for long-term health considerations. In this paper, the dietary exposure to radionuclides (210Pb, 210Po, 226Ra, 2...
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Open AccessSpatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucle...
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Article
Open AccessDivergent patterns of selection on metabolite levels and gene expression
Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes involved in ergosterol biosynthesis—an esse...
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Open AccessTRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER) homeostasis under adverse conditions, yet the underlying mechanisms are not well defined. Here, through the evaluation of all...
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Open AccessKS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
Uveitis is a potentially sight-threatening form of ocular inflammation that affects the uvea in the wall of the eye. Currently available treatments for uveitis have exhibited profound adverse side effects. How...
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Open AccessThe lncRNA Neat1 promotes activation of inflammasomes in macrophages
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes. Neat1 associates with the...
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Open AccessTAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p...
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Open AccessTRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
The proteasome is a complex protease critical for protein quality control and cell regulation, and its dysfunction is associated with cancer and other diseases. However, the mechanisms that control proteasome ...
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Open AccessGenetic variations in ARE1 mediate grain yield by modulating nitrogen utilization in rice
In crops, nitrogen directly determines productivity and biomass. However, the improvement of nitrogen utilization efficiency (NUE) is still a major challenge in modern agriculture. Here, we report the characte...
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Open AccessChanges in Retinal Nerve Fiber Layer Thickness after Multiple Injections of Novel VEGF Decoy Receptor Conbercept for Various Retinal Diseases
Conbercept is a recombinant fusion protein with high affinity for all vascular endothelial growth factor isoforms and placental growth factor. The repeated intravitreal injection of conbercept may cause intrao...
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Apoptotic regulation and tRNA
Apoptotic regulation is critical to organismal homeostasis and protection against many human disease processes such as cancer. Significant research efforts over the past several decades have illuminated many s...