5 Result(s)
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**aoli S. Wu
Science, Humanities and Social Sciences, multidisciplinary
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Article
BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network
Inhibition of the tumour suppressive function of p53 (encoded by TP53) is paramount for cancer development in humans. However, p53 remains unmutated in the majority of cases of glioblastoma (GBM)—the most common ...
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Article
Open AccessSirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity
Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs to the NAD+-dependent deacetylases and has established ...
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Article
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses to foreign pathogens in mucosal tissues1. Recent studies have also revealed tuft-cell-like human tumours2,3, particularly as...
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Article
Open AccessBAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype is characterized by t(2;13) or t(1;13) translocations encoding for PAX3- or PAX7-FOXO1 chimeric tran...
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Article
Open AccessUnveiling Tatun volcanic plumbing structure induced by post-collisional extension of Taiwan mountain belt
The Tatun Volcanic Group (TVG) is proximal to the metropolis of Taipei City (population of ca. 7 million) and has long been a major concern due to the potential risks from volcanic activity to the population a...
