27 Result(s)

Article

ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation

The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a uniqu...

Yuan Gao, Xue-Yan He, **aoli S. Wu, Yu-Han Huang, Shushan Toneyan… in Nature Cell Biology (2023)

Article

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network

Inhibition of the tumour suppressive function of p53 (encoded by TP53) is paramount for cancer development in humans. However, p53 remains unmutated in the majority of cases of glioblastoma (GBM)—the most common ...

Xueqin Sun, Olaf Klingbeil, Bin Lu, Caizhi Wu, Carlos Ballon, Meng Ouyang… in Nature (2023)

Article

OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage

Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses to foreign pathogens in mucosal tissues¹. Recent studies have also revealed tuft-cell-like human tumours^2,3, particularly as...

**aoli S. Wu, Xue-Yan He, Jonathan J. Ipsaro, Yu-Han Huang, Jonathan B. Preall… in Nature (2022)

Chapter

The Statehood of Taiwan

According to Article 1 in the Montevideo Convention on the Rights and Duties of States in 1933, the necessary components of a “state” consist of (a) a permanent population, (b) a defined territory, (c) a gover...

Hsuan-Yu Shane Lin, Charles K. S. Wu, Yao-Yuan Yeh in China and Taiwan in Africa (2022)

Article

A pliable ERα cistrome evades therapy

The transcription factor oestrogen receptor alpha (ERα) has long been targeted for therapeutic benefit in cancer, but drug resistance can emerge through a multitude of mechanisms. A study now reveals how the E...

**aoli S. Wu, Christopher R. Vakoc in Nature Cell Biology (2020)

Article

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here...

Berkley E. Gryder, Silvia Pomella, Carly Sayers, **aoli S. Wu… in Nature Genetics (2019)

Article

DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Pro...

C. E. Aalseth, F. Acerbi, P. Agnes… in The European Physical Journal Plus (2018)

Article

The effect of precipitated calcium carbonate nanoparticles in coatings

The insertion of nanoparticles into some industrial materials can give them special properties due to their high reactivity. These nanoparticles interact with other particles, changing and/or improving the fi...

W. S. Wu, M. E. Queiroz, N. D. S. Mohallem in Journal of Coatings Technology and Research (2016)

Article

Isolation and characterzation of endophytic Huperzine A-producing fungi from Phlegmariurus phlegmaria

Based on special colony morphology, 340 endophytic fungi were isolated from the stems, leaves, and roots of Phlegmariurus phlegmaria. Among the 340 strains, eight, representative species (MY298, MJ216, MY237, MJ4...

F. F. Zhang, M. Z. Wang, Y. X. Zheng, H. Y. Liu, X. Q. Zhang, S. S. Wu in Microbiology (2015)

Article

Effects of organic acids on Eu(III) sorption on Na-bentonite

Sorption of Eu(III) on Na-bentonite dispersed in sodium chloride media was studied as a function of pH via batch-type experiments. The sorption was found increased with the increasing pH. The sorption kinetics...

N. Guo, J. W. Yang, R. Zhang, Y. L. Ye… in Journal of Radioanalytical and Nuclear Che… (2015)

Article

Treatment of Osteonecrosis in Systemic Lupus Erythematosus: A Review

Osteonecrosis (ON) is a devastating illness that can lead to severe joint disease in young patients. The pathogenesis of ON is largely unknown; however, there have been numerous reports associating risk factor...

T. Andrew Ehmke, Jeffrey J. Cherian, Eddie S. Wu… in Current Rheumatology Reports (2014)

Article

Argument reduction and anaphora resolution: the case of xiang−verbs in Mandarin Chinese

In this paper, I discuss argument reduction and anaphora resolution of xiang−verbs in Mandarin Chinese. When xiang is prefixed to a verbal stem, one of the arguments of the verbal stem is absorbed, xiang function...

J. -S. Wu in Journal of East Asian Linguistics (2012)

Article

Book reviews

Wicky W. K. Tse, Pei-Ying Lin, Guo Wu, Emily S. Wu… in Frontiers of History in China (2011)