17 Result(s)
-
Article
Open AccessIn vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy
Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, the wide application of GPX4...
-
Article
Open AccessChromosomal-scale genome assembly and annotation of the land slug (Meghimatium bilineatum)
Meghimatium bilineatum is a notorious pest land slug used as a medicinal resource to treat ailments in China. Although this no-model species is unique in terms of their ecological security and medicinal value, th...
-
Article
Open AccessDynamic response of deepwater test string under fluctuations in axial force and internal pressure
In this study, a mechanical model suitable for deepwater test string was proposed. An analysis of the dynamic response of the test string under different frequencies, different water depths and different fluct...
-
Article
Open AccessGPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression
Regulatory T cells (Tregs) are critically involved in neovascularization, an important compensatory mechanism in peripheral artery disease. The contribution of G protein coupled receptor 174 (GPR174), which is...
-
Article
Open AccessGold nanoclusters eliminate obesity induced by antipsychotics
Obesity induced by antipsychotics have plagued more than 20 million people worldwide. However, no drug is available to eliminate the obesity induced by antipsychotics. Here we examined the effect and potential...
-
Article
Open AccessSingle-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
Human FOXP3+ regulatory T (Treg) cells are central to immune tolerance. However, their heterogeneity and differentiation remain incompletely understood. Here we use single-cell RNA and T cell receptor sequencing ...
-
Article
Open AccessNitrogen and boron doped carbon layer coated multiwall carbon nanotubes as high performance anode materials for lithium ion batteries
Lithium ion batteries (LIBs) are at present widely used as energy storage and conversion device in our daily life. However, due to the limited power density, the application of LIBs is still restricted in some...
-
Article
Open AccessA Systematic Review and Meta-analysis of the Topical Administration of Fibrin Sealant in Total Hip Arthroplasty
Patients who undergo total hip arthroplasty (THA) may experience a large amount of blood loss. The objective of our study is to include randomized controlled trials (RCTs) and compare the clinical outcomes of ...
-
Article
Open AccessHydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
Multisite phosphorylation is an important and common mechanism for finely regulating protein functions and subsequent cellular responses. However, this study is largely restricted by the difficulty to capture ...
-
Article
Open AccessLkb1 maintains Treg cell lineage identity
Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features a...
-
Article
Open AccessThe histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression is downregulated in the heart ...
-
Article
Open AccessEgg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway
Schistosomiasis is characterized by egg deposition, granulomatous inflammatory reaction and then subsequent hepatic fibrosis formation. Activated HSCs are regarded as the main effector cells in the progression...
-
Article
Open AccessSialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching
Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, i...
-
Article
Open AccessNaringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone
Naringin maintains bone mass in various osteoporosis models, while its effect on bone in disuse osteoporosis has not been reported. The present study explores whether naringin can prevent disuse osteoporosis i...
-
Article
Open AccessCH-π Interaction Driven Macroscopic Property Transition on Smart Polymer Surface
Life systems have evolved to utilize weak noncovalent interactions, particularly CH-π interaction, to achieve various biofunctions, for example cellular communication, immune response and protein folding. Howe...
-
Article
Open AccessThe Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats
Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naring...
-
Article
Open AccessFree-standing Fe2O3 nanomembranes enabling ultra-long cycling life and high rate capability for Li-ion batteries
With Fe2O3 as a proof-of-concept, free-standing nanomembrane structure is demonstrated to be highly advantageous to improve the performance of Li-ion batteries. The Fe2O3 nanomembrane electrodes exhibit ultra-lon...
