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  1. No Access

    Article

    Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel therapeutic strategy for different molecular types of breast cancer

    Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell cycle progression. Moreover, CD...

    Xue Song, Chen Fang, Yan Dai, Yang Sun, Chang Qiu, **aojie Lin… in British Journal of Cancer (2024)

  2. Article

    Open Access

    Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis

    Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as a hallmark of POCD. However, safe and e...

    **angyi Kong, Wenyuan Lyu, **aojie Lin, Chunlong Lin… in Journal of Neuroinflammation (2024)

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    Article

    Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography

    A rodent model of embolic middle cerebral artery occlusion is used to mimic cerebral embolism in clinical patients. Thrombolytic therapy is the effective treatment for this ischemic injury. However, it is diff...

    Li** Wang, Panting Zhou, Zhihao Mu, **aojie Lin… in Translational Stroke Research (2019)

  4. No Access

    Protocol

    Stimulation of Cerebral Angiogenesis by Gene Delivery

    Angiogenesis, an important process for long term neurological recovery, could be induced by ischemic brain injury. In this chapter, we describe a system to deliver adeno-associated viral (AAV) vector-mediated ...

    Yaohui Tang, Yaning Li, **aojie Lin, Peng Miao, Yongting Wang… in Cerebral Angiogenesis (2014)