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Article
Synergistic asymmetric diarylation of tethered alkenes via C–H functionalization of simple (hetero)arenes
By virtue of the atom- and step-economy, utilization of simple arenes as a supplant of pre-prepared aryl metal species or aryl halides for the synthesis of arylated chiral molecules has attracted great attenti...
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Article
Synergistic silver-mediated and palladium-catalyzed nondirected olefination of aryl C–H bond: quick access to multi-substituted aryl olefins
Transition metal-catalyzed olefination of aryl C–H bond is a powerful tool for the synthesis of alkenes. While the Pd-catalyzed oxidative C–H olefination of arenes, also known as Fujiwara-Moritani reaction, ha...
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Article
Open AccessPrediction of chemical reaction yields with large-scale multi-view pre-training
Develo** machine learning models with high generalization capability for predicting chemical reaction yields is of significant interest and importance. The efficacy of such models depends heavily on the repr...
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Article
Synergistic catalysis for stereocontrol of prochiral nucleophiles in palladium-catalyzed asymmetric allylic substitution
In contrast to the stereocontrol of the stereocenter at the allyl unit, the asymmetric induction of prochiral nucleophiles remains a challenge in Pd-catalyzed asymmetric allylic substitutions due to the remote...
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Article
Asymmetric synthesis of bedaquiline based on bimetallic activation and non-covalent interaction promotion strategies
Bedaquiline (BDQ), approved by Food and Drug Administration (FDA) in 2012 as the first anti-tuberculosis-specific drug in the last 40 years, is viewed as one of the world’s most promising treatments for tuberc...