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Article
Open AccessGreatly isolated heterogeneous circulating tumor cells using hybrid engineered cell membrane-camouflaged magnetic nanoparticles
Circulating tumor cells (CTCs) are considered as a useful biomarker for early cancer diagnosis, which play a crucial role in metastatic process. Unfortunately, the tumor heterogeneity and extremely rare occurr...
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Article
Open AccessCorrelation between dynamic contrast-enhanced MRI characteristics and apparent diffusion coefficient with Ki-67-positive expression in non-mass enhancement of breast cancer
As a remarkably specific characteristic of breast cancer observed on magnetic resonance imaging (MRI), the association between the NME type breast cancer and prognosis, including Ki-67, necessitates comprehens...
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Article
Open AccessAgrochemical exposure-induced seed microbiome response in barley
The seed microbiota has great potential for enhancing agricultural practices and promoting sustainable plant growth. However, excessive and improper application of agrochemicals may have unforeseen effects on ...
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Article
Enhanced biological stabilization of metal-chelant complexes in the chelator-washed soils by sulfate-reducing bacteria
Sulfate-reducing bacteria (SRB) is considered a promising bioremediation technology for stabilization of metals in soil. The study investigated the stabilization efficiencies of metal-chelant complexes by SRB ...
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Effect of multiple washing operations on the removal of potentially toxic metals from an alkaline farmland soil and the strategy for agricultural reuse
Few studies have carried out soil washing experiments using pot experiments to simulate in situ soil washing operations, particularly for alkaline soils. This study explored the effects of multiple washing ope...
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Article
Open AccessPopulation genetic structure and evolutionary genetics of Anopheles sinensis based on knockdown resistance (kdr) mutations and mtDNA-COII gene in China–Laos, Thailand–Laos, and Cambodia–Laos borders
Vector control is still a pivotal method for preventing malaria, and its potency is weakened by the increasing resistance of vectors to chemical insecticides. As the most abundant and vital malaria vector in S...
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Article
FKBP51 Contributes to Uterine Leiomyoma Pathogenesis by Inducing Cell Proliferation and Extracellular Matrix Deposition
The FK506-binding protein 51 (FKBP51) binds progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR) to coregulate their transcriptional activity. We evaluated FKBP51 expression and...
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Article
Evolutionary analysis of a newly isolated Banna virus strain from Yunnan, China
Banna virus (BAV) is a typical arbovirus whose infection is associated with fever and viral encephalitis. The whole genome of BAV is composed of 12 RNA segments. BAVs, which have been divided into three genoty...
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Article
Open AccessMorphological and molecular identification reveals a high diversity of Anopheles species in the forest region of the Cambodia–Laos border
To develop an effective malaria vector intervention method in forested international border regions within the Greater Mekong Subregion (GMS), more in-depth studies should be conducted on local Anopheles species ...
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Article
Open AccessAnalysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder diagnosed during adolescence and adulthood. Assessment of the long-term risks of the current drugs for ADHD treatment has been i...
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Article
Open AccessMolecular phylogeny of the Anopheles hyrcanus group (Diptera: Culicidae) based on rDNA–ITS2 and mtDNA–COII
The Anopheles hyrcanus group, which includes 25 species, is widely distributed in the Oriental and Palaearctic regions. Given the difficulty in identifying cryptic or sibling species based on their morphological ...
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Article
Open AccessDeepHBV: a deep learning model to predict hepatitis B virus (HBV) integration sites
The hepatitis B virus (HBV) is one of the main causes of viral hepatitis and liver cancer. HBV integration is one of the key steps in the virus-promoted malignant transformation.
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Article
The construction of high precision geostrophic currents based on new gravity models of GOCE and satellite altimetry data
The new gravity field models of gravity field and steady-state ocean circulation explorer (GOCE), TIM_R6 and DIR_R6, were released by the European Space Agency (ESA) in June 2019. The sixth generation of gravi...
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Article
Identification and Molecular Characterization of a New Omono River Virus Isolated from Culex Tritaeniorhynchus in Yunnan, China
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Open AccessPrevalence and genotype distribution of group A rotavirus circulating in Shanxi Province, China during 2015–2019
Group A rotavirus (RVA), despite being a leading cause of gastroenteritis in infants and young children, is less studied in Shanxi Province, China. The current study was conducted to determine the prevalence a...
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Article
Complete genome sequence of a novel bovine hepacivirus from Yunnan, China
We detected a novel bovine hepacivirus N (HNV) subtype, IME_BovHep_01, in the serum of cattle in Tengchong, Yunnan, China, by high-throughput sequencing. The complete genome of IME_BovHep_01, was sequenced usi...
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Article
Open AccessThe mitohormetic response as part of the cytoprotection mechanism of berberine
It was well-known that Berberine, a major bioactive compound extracted from natural plants Coptis chinensis, has anti-diabetic effects for decades in china. Other types of pharmacological activities, such as anti...
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Article
Revitalization of Mixed Chelator–Washed Soil by Adding of Inorganic and Organic Amendments
Soil washing is an effective technology for the remediation of soils contaminated with various metals. However, the bioavailability of residual metals in soils and soil properties can be changed during the was...
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Article
Complete genome sequence of a novel negevirus isolated from Culex tritaeniorhynchus in China
A novel negevirus, tentatively named Manglie virus (MaV), was isolated from Culex tritaeniorhynchus from the village of Manglie, Yunnan, China, in August 2011. It was identified by high-throughput sequencing of c...
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Article
Levels of persistent toxic substances in different biochars and their potential ecological risk assessment
This study investigated the levels of persistent toxic substances, such as 16 polycyclic aromatic hydrocarbons (Σ16PAHs) and heavy metals (Cu, As, Cd, Zn, Pb, Ni, Mo, and Cr) in biochars produced from crop res...
