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Article
Open AccessOptimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue
Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry (IHC) is the golden standard in predicting immunotherapy response of non-small cell lung cancer (NSCLC). However, observation...
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Low cost and low density chloride solid electrolyte for all solid state cathode with high active material ratio
Chloride solid electrolytes (SEs) have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode compatibility. However, the conventionally selected central met...
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Article
Open AccessN6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, ...
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Article
GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures
Neuroinflammation is being increasingly recognized as a vital factor in the development of various neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an outer membrane component of gram-neg...
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Article
Heavy ion energy influence on multiple-cell upsets in small sensitive volumes: from standard to high energies
The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened devices. However, owing to the minimum physical gate length of only 35 nm, the phys...
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Article
Open AccessSyndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In cont...
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Article
Supramolecular systems for bioapplications: recent research progress in China
Supramolecular systems feature dynamic, reversible and stimuli-responsive characteristics, which are not easily achieved by molecular entities. The last decade has witnessed tremendous advances in the investig...
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Article
The effect of feeding on different hosts on the egg proteins in Haemaphysalis qinghaiensis tick
The majority of ixodid ticks display host-specificity to varying extents. Feeding on different hosts affects their development and reproduction. Consequences can be analyzed at the level of the egg, as it is t...
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Article
Effect of Artificial Cooling Extrusion on Microstructure and Mechanical Properties of Mg–Zn–Y Alloys
Microstructure and mechanical properties of Mg–Zn–Y alloys with different Zn/Y atomic ratios with or without artificial cooling (AC) extrusion were systematically investigated in this work. The results show th...
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Article
Prevalence and molecular characterization of Cryptosporidium spp., Enterocytozoon bieneusi, and Giardia duodenalis in dairy cattle in Ningxia, northwestern China
Cryptosporidium spp., Enterocytozoon bieneusi, and Giardia duodenalis are common intestinal pathogens that infect humans and animals. To date, research regarding these three protozoa in the Ningxia Hui Autonomous...
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Article
Erratum to: A robust indium-organic framework with open tubular channels for efficient separation of acetylene
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Article
A robust indium-organic framework with open tubular channels for efficient separation of acetylene
Considering the tremendous applications and purification requirement of acetylene (C2H2), seeking appropriate adsorbents with high capacity and selectivity is a vital task and remains an enduring challenge. Herei...
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Article
Effects of toroidal rotation and ion collisional viscosity on low-frequency zonal flow in tokamak plasma
Theoretical investigations are conducted to examine the impact of toroidal rotation and ion collisional viscosity on low-frequency zonal flow (LFZF) in a tokamak plasma with the fluid model. The results indica...
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Article
Open AccessClinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency
The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of non-classical 21-hydroxylase deficiency. For this study, we investigated the relationship between the clin...
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Article
Open AccessiNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse
Toxoplasma gondii is an obligate intracellular parasite of rodents and humans. Interferon-inducible guanylate binding proteins (GBPs) are mediators of T. gondii clearance, however, this mechanism is incomplete. H...
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Article
Open AccessA radiomics-based interpretable model to predict the pathological grade of pancreatic neuroendocrine tumors
To develop a computed tomography (CT) radiomics-based interpretable machine learning (ML) model to predict the pathological grade of pancreatic neuroendocrine tumors (pNETs) in a non-invasive manner.
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Article
Open AccessEnhancing the Interaction of Carbon Nanotubes by Metal–Organic Decomposition with Improved Mechanical Strength and Ultra-Broadband EMI Shielding Performance
A strategy based on metal-organic decomposition is proposed to enhance the tube-tube interactions of carbon nanotubes (CNTs).
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Article
Open AccessDipterocarpoidae genomics reveal their demography and adaptations to Asian rainforests
Dipterocarpoideae species form the emergent layer of Asian rainforests. They are the indicator species for Asian rainforest distribution, but they are severely threatened. Here, to understand their adaptation ...
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Article
Research on the knee region of cosmic ray by using a novel type of electron–neutron detector array
By accurately measuring composition and energy spectrum of cosmic ray, the origin problem of so called “knee” region (energy >one PeV) can be solved. However, up to the present, the results of the spectrum in ...
