59 Result(s)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells

Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); howev...

Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen… in Journal of Experimental & Clinical Cancer … (2023)

Article

Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain

Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior cingulate cortex (ACC) has been demonstrated to be associated with pain and...

Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen… in Journal of Neuroinflammation (2023)

Article

Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML

Cytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML patients. The expression of SAM...

Feifei Zhang, Jun Sun, **aofeng Tang, Yi** Liang, Quanhui Jiao… in Cell Death & Disease (2022)

Article

Rasmussen’s encephalitis is characterized by relatively lower production of IFN-β and activated cytotoxic T cell upon herpes viruses infection

The etiology of Rasmussen's encephalitis (RE), a rare chronic neurological disorder characterized by CD8+ T cell infiltration and unihemispheric brain atrophy, is still unknown. Various human herpes viruses (H...

Yi-Song Wang, Dong Liu, **n Wang, Qiao-Li Luo, Ling Ding… in Journal of Neuroinflammation (2022)

Article

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization

Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy induction is one of the hallmark effects of anti-GB...

Zhuang Li, Wen-Juan Fu, **ao-Qing Chen… in Journal of Experimental & Clinical Cancer … (2022)

Article

Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

Tumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation and cancer metastasis. However,...

Chong Zhang, **ang-Yu Wang, Peng Zhang, Tao-Chen He, Jia-Hao Han… in Cell Death & Disease (2022)

Article

CD4+ effector T cells accelerate Alzheimer’s disease in mice

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodege...

Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster… in Journal of Neuroinflammation (2021)

Article

SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop

Small nucleolar RNA host gene (SNHG) long noncoding RNAs (lncRNAs) are frequently dysregulated in human cancers and involved in tumorigenesis and progression. SNHG17 has been reported as a candidate oncogene i...

Zehua Bian, Mingyue Zhou, Kaisa Cui… in Journal of Experimental & Clinical Cancer … (2021)

Article

Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu… in Journal of Experimental & Clinical Cancer … (2021)

Article

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the fun...

**ao Yang, Jia-shun Wu, Mao Li… in Journal of Experimental & Clinical Cancer … (2021)

Article

Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease

Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profib...

Bohan Chen, Pei Wang, **anhui Liang, Chunming Jiang, Yan Ge… in Cell Death & Disease (2021)

Article

Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients

Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially the S1 protein, is one of the major reagents used for serological t...

Yang Li, Dan-yun Lai, Qing Lei, Zhao-wei Xu, Feng Wang… in Cellular & Molecular Immunology (2021)

Article

TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain

Neonatal hypoxic-ischemic brain damage (HIBD), a leading cause of neonatal mortality, has intractable sequela such as epilepsy that seriously affected the life quality of HIBD survivors. We have previously sho...

**n Wang, **ng-Liang Yang, Wei-Lin Kong, Meng-Liu Zeng… in Journal of Neuroinflammation (2019)

Article

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal cancer (CRC) remain largely unknown. Besides, tumor-ass...

Zhen-xing Liang, Hua-shan Liu, Feng-wei Wang, Li **ong, Chi Zhou… in Cell Death & Disease (2019)

Article

Ca²⁺-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excita...

Hao-Song Shi, Ke Lai, **n-Lu Yin, Min Liang, Hai-Bo Ye, Hai-Bo Shi… in Cell Death & Disease (2019)

Article

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and develo** countries. Children surviving from HIE often have severe long-term sequela including ce...

**ng-Liang Yang, **n Wang, Lin Shao, Guang-Tong Jiang… in Journal of Neuroinflammation (2019)

Article

CD45⁺CD33^lowCD11b^dim myeloid-derived suppressor cells suppress CD8⁺ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer

Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gast...

Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng… in Cell Death & Disease (2018)

Article

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Hematopoietic stem cells (HSCs) can give rise to all blood cells that are essential to defend against pathogen invasion. The defective capability of HSC self-renewal is linked to many serious diseases, such as...

Ting Liu, Wei-xia Kong, **ao-yi Tang, Man Xu, Qing-han Wang… in Cell Death & Disease (2018)

Article

Helicobacter pylori-induced IL-33 modulates mast cell responses, benefits bacterial growth, and contributes to gastritis

Interleukin (IL)-induced inflammatory responses are critical for the pathogenesis of Helicobacter pylori (H. pylori)-induced gastritis. IL-33 represents a recently discovered proinflammatory cytokine involved in ...

Yi-pin Lv, Yong-sheng Teng, Fang-yuan Mao, Liu-sheng Peng… in Cell Death & Disease (2018)