2,906 Result(s)
within
**ao-li Zhang
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Article
Open AccessAngelicin improves osteoporosis in ovariectomized rats by reducing ROS production in osteoclasts through regulation of the KAT6A/Nrf2 signalling pathway
Angelicin, which is found in Psoralea, can help prevent osteoporosis by stop** osteoclast formation, although the precise mechanism remains unclear.
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D-band center coordination modulated enzyme-like activity in Fe-Cu dual-metal single-atom nanozymes
After explorations in a diversity of single-atom nanozymes (SAzymes), develo** dual-centered SAzymes becomes a promising approach for superior catalytic performance. But confusing mechanisms including atomic...
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Two sex pheromone receptors for sexual communication in the American cockroach
Volatile sex pheromones are vital for sexual communication between males and females. Females of the American cockroach, Periplaneta americana, produce and emit two sex pheromone components, periplanone-A (PA) an...
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Multiscale engineering of molecular electrocatalysts for the rapid hydrogen evolution reaction
Molecular electrocatalysts have demonstrated potential for the hydrogen evolution reaction (HER) due to their well-defined structures and high intrinsic activities. Achieving rapid production of hydrogen requi...
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Experimental investigation of vibration pretreatment-microwave curing process for carbon fiber reinforced resin matrix composites
The vibration pretreatment-microwave curing process is an efficient, low energy consumption, and high-quality out-of-autoclave curing process for carbon fiber resin matrix composites. This study aims to invest...
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Characteristics of secondary microseisms generated in the Bohai Sea and their impact on seismic noise
In this study, we use the Bohai Sea area as an example to investigate the characteristics of secondary microseisms and their impact on seismic noise based on the temporal frequency spectral analysis of observa...
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H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
Photodynamic therapy (PDT) has been emerged as a promising modality for cancer treatment. However, the development of drug delivery system enabling continuous release of photosensitizers (PSs) for long-term PD...
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A machine learning-based calibration method for strength simulation of self-piercing riveted joints
This paper presents a new machine learning-based calibration framework for strength simulation models of self-piercing riveted (SPR) joints. Strength simulations were conducted through the integrated modeling ...
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Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of MSC-EVs pose a potential risk of thromboembolism, an issue tha...
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From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine **aoyaosan
The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly reduced in patients with depression, which severely disrupts hippo...
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Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following thrombolysis and endovascular therapy. There is no approved drug in th...
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Recent advances in glycerol valorization through electrocatalytic methods
The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this process. This sparked attention towards glycerol use an...
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Structural basis of tolvaptan binding to the vasopressin V2 receptor
The vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist. Herein, we used Gaussian accel...
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Open AccessBiosynthesis of GMGT lipids by a radical SAM enzyme associated with anaerobic archaea and oxygen-deficient environments
Archaea possess characteristic membrane-spanning lipids that are thought to contribute to the adaptation to extreme environments. However, the biosynthesis of these lipids is poorly understood. Here, we identi...
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One-neutron strip** process in the 209Bi(6Li, 5Li)210Bi* reaction reaction
One-neutron strip** process between \(^{6}\) 6 ...
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Open AccessAn electrochemically responsive B–O dynamic bond to switch photoluminescence of boron-nitrogen-doped polyaromatics
Boron-doped polycyclic aromatic hydrocarbons exhibit excellent optical properties, and regulating their photophysical processes is a powerful strategy to understand the luminescence mechanism and develop new m...
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessLABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA
Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...
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Simulation of the in-flight background and performance of DRO/GTM
As a new member of the high energy astronomical transient monitoring network, Gamma-ray Transient Monitor (GTM) is an all-sky monitor onboard the Distant Retrograde Orbit (DRO) mission which has been launched ...
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Open AccessComparative transcriptome analysis reveals genes involved in trichome development and metabolism in tobacco
The glandular trichomes of tobacco (Nicotiana tabacum) can efficiently produce secondary metabolites. They act as natural bioreactors, and their natural products function to protect plants against insect-pests an...
