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  1. No Access

    Article

    Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice

    Cognitive and behavioral rigidity are observed in various psychiatric diseases, including in autism spectrum disorder (ASD). However, the underlying mechanism remains to be elucidated. In this study, we found ...

    Shen Lin, Cui-ying Fan, Hao-ran Wang, **ao-fan Li, Jia-li Zeng… in Molecular Psychiatry (2024)

  2. Article

    Open Access

    EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

    Platelet-derived growth subunit A (PDGFA) plays critical roles in development of glioblastoma (GBM) with substantial evidence from TCGA database analyses and in vivo mouse models. So far, only platelet-derived...

    Qu-**g Gai, Zhen Fu, Jiang He, Min Mao… in Signal Transduction and Targeted Therapy (2022)

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  3. Article

    Open Access

    Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

    It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

    Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

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  4. No Access

    Article

    Effect of Yiqi Tongyang Decoction (益气通阳方) on blood T cell subsets in patients with chronic immune thrombocytopenia

    To measure the proportions of blood T cell subsets, Th1, Th2, Th17, Th22, and Treg cells, and other parameters in patients with chronic immune thrombocytopenia (CITP) before and after treatment with Yiqi Tongy...

    **u-peng Yang, Rou Ma, **ao-hong Yang… in Chinese Journal of Integrative Medicine (2017)

  5. No Access

    Article

    Effects of sodium copper chlorophyllin on mesenchymal stem cell function in aplastic anemia mice

    To investigate the effects of sodium copper chlorophyllin (SCC) on the proliferation, differentiation and immunomodulatory function of mesenchymal stem cells (MSCs) from mice with aplastic anemia.

    Li-ming Yin 尹利明, Hui-fang Jiang 蒋慧芳… in Chinese Journal of Integrative Medicine (2013)

  6. No Access

    Article

    Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells

    To investigate the effects of panax notoginseng saponins (PNS) on expression, regulation and phosphorylation of multiple protein kinases in mitogen activated protein kinase (MAPK) intracellular signal pathway ...

    **n Sun 孙 馨, Rui-lan Gao 高瑞兰, **ao-jie Lin 林筱洁… in Chinese Journal of Integrative Medicine (2013)

  7. No Access

    Article

    Effects of Panax notoginseng saponins on proliferation and differentiation in NIH3T3 cells

    To investigate the effects of Panax notoginseng saponins (PNS) on the proliferation and differentiation in NIH3T3 cells.

    Li-ming Yin 尹利明, **ao Wang 王 潇, Xu-dai Qian 钱煦岱… in Chinese Journal of Integrative Medicine (2012)

  8. No Access

    Article

    Influence of p53 small double stranded RNA interference on hepatoma cell line SK-HEP-1

    Objective: The effects on cell-cycle and p53 expression in hepatoma cell line SK-Hep-1 were explored by transfecting exogenous p53 small double stranded RNA (dsRNA) into the SK-Hep-1 cell...

    **ao-zhe Cao, Ming-hua Zhu, Zhi Zhu, Fei Feng… in Chinese Journal of Cancer Research (2005)