39 Result(s)

Article

PD-L1 inhibitor versus PD-1 inhibitor plus bevacizumab with transvascular intervention in unresectable hepatocellular carcinoma

Both atezolizumab (a PD-L1 inhibitor) plus bevacizumab (A+B) and sintilimab (a PD-1 inhibitor) plus bevacizumab (S+B) are recommended as the first-line regimen for advanced hepatocellular carcinoma (HCC) in Ch...

Zhenkun Huang, Tiejun Chen, Wenbin Li, Jiliang Qiu… in Clinical and Experimental Medicine (2024)

Article

Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes

The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...

Jie Tian, Yong-** Song, Gao-Chong Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage...

Jie **ong, Shu Cheng, **ao Gao, Shan-He Yu… in Signal Transduction and Targeted Therapy (2024)

Article

Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of autophagy, the innate immune response, and cell differentiation, their roles in skeletal diseases are largely unkno...

Ri-Xu Liu, Rong-He Gu, Zhi-Peng Li, Zhi-Quan Hao, Qin-**ao Hu, Zhen-Yan Li… in Bone Research (2023)

Article

TRIM69: a marker of metastasis and potential sensitizer to 5-Fluorouracil and PD-1 blockers in colon adenocarcinoma

Several proteins in the tripartite-motif (TRIM) family are associated with the development of colorectal cancer (CRC), but research on the role of TRIM69 was lacking. The present study examined the correlation...

**ao-Jv Chi, Yi-Bei Song, Deng-He Liu, Li-Qiang Wei, An-Ran Zhao… in BMC Gastroenterology (2023)

Article

Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study

Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang_syn) with good curative effect and security. However, BGZ was also...

Ming-Liang Zhang, Xu Zhao, Wei-**a Li, **ao-Yan Wang, Ming Niu… in Chinese Medicine (2023)

Article

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial

This study was conducted to observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on the postoperative sleep quality of patients undergoing gastrointestinal tumor surgery and to verify t...

Jun Wang, Fei-Fei Lu, Miao-Miao Ge, Li-Wen Wang, Gang Wang… in Pain and Therapy (2023)

Article

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma

The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effective therapeutic strategy for these patients is urgently needed. Although ubiquitin-spe...

**-Ya Li, Ji-Chuan Wu, ** Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen… in Leukemia (2023)

Article

Treatment and surveillance for non-muscle-invasive bladder cancer: a clinical practice guideline (2021 edition)

Non-muscle invasive bladder cancer (NMIBC) is a major type of bladder cancer with a high incidence worldwide, resulting in a great disease burden. Treatment and surveillance are the most important part of NIMB...

Ying-Hui **, **an-Tao Zeng, Tong-Zu Liu, Zhi-Ming Bai… in Military Medical Research (2022)

Article

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed that irreversible myoca...

**ao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu… in Signal Transduction and Targeted Therapy (2022)

Article

Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2)

LCAR-B38M is a chimeric antigen receptor T cell product with two binding domains targeting B cell maturation antigen. Our previous reports showed a remarkable efficacy of LCAR-B38M in patients with relapsed/re...

Wan-Hong Zhao, Bai-Yan Wang, Li-Juan Chen, Wei-Jun Fu… in Journal of Hematology & Oncology (2022)

Article

Applications of mPCR testing reduced initial antibiotic use and duration of mechanical ventilation in virus-infected children with severe community-acquired pneumonia admitted to the PICU

Chao-Nan Fan, Bo-Liang Fang, Heng-Miao Gao, Ru-Bo Li… in World Journal of Pediatrics (2022)

Article

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Tran...

**an-Tao Zeng, Ying-Hui **, Tong-Zu Liu, Fang-Ming Chen… in Military Medical Research (2022)

Article

The association of demodex infestation with pediatric chalazia

This study aimed to investigate the association of Demodex infestation with pediatric chalazia.

**g Huang, Meng-**ang Guo, Dao-Man **ang, Li-Feng Yan, Ying Yu… in BMC Ophthalmology (2022)

Article

Active demethylation upregulates CD147 expression promoting non-small cell lung cancer invasion and metastasis

Non-small cell lung cancer (NSCLC) is a fatal disease, and its metastatic process is poorly understood. Although aberrant methylation is involved in tumor progression, the mechanisms underlying dynamic DNA met...

Cheng-Gong Liao, **ao-Hua Liang, Yuan Ke, Li Yao, Man Liu, Ze-Kun Liu, Lin He… in Oncogene (2022)

Article

Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway

Qingwei San (QWS), one of classic Chinese Medicine prescripts, has been widely used to treat stomach heat syndrome which manifests oral ulcer (OU), periodontitis and upper gastrointestinal bleeding for seven h...

Lu Shi, Yongcheng An, Long Cheng, Yiyang Li, Huimin Li, Chen Wang… in Chinese Medicine (2022)

Article

Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China

Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the se...

**ao-Lei Ye, Ke Dai, Qing-Bin Lu, Yan-Qin Huang… in Infectious Diseases of Poverty (2021)

Article

Quantitative assessment and determinants of the papillary microvasculature in healthy subjects

It is critical to monitor the optic disc’s vessel density using Optical coherence tomography angiography (OCTA) and evaluate its determinants. In the current study, we investigate the superficial vessel densit...

Li-jun Zhou, **u-zhi Luo, Pei-yang Shen, **n Li, Peng Su, Zhe Zhu… in BMC Ophthalmology (2021)

Article

Clinical characteristics of 41 patients with pneumonia due to 2019 novel coronavirus disease (COVID-19) in Jilin, China

The clinical characteristics of patients with confirmed 2019 novel coronavirus disease (COVID-19) in Jilin Province, China were investigated.

Qing Zhang, Qian Xu, Yi-yang Chen, Li-xin Lou, Li-he Che… in BMC Infectious Diseases (2020)

Article

Comparison of patients hospitalized with COVID-19, H7N9 and H1N1

There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that the coronavirus disease 2019 (COVID-19) continues to cause considerabl...

Li-Si Deng, **g Yuan, Li Ding, Yuan-Li Chen… in Infectious Diseases of Poverty (2020)