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Article
Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
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Article
Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse, posing significant safety risks. However, previous theoretical studies on the range of ...
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Article
Open AccessPD-L1 inhibitor versus PD-1 inhibitor plus bevacizumab with transvascular intervention in unresectable hepatocellular carcinoma
Both atezolizumab (a PD-L1 inhibitor) plus bevacizumab (A+B) and sintilimab (a PD-1 inhibitor) plus bevacizumab (S+B) are recommended as the first-line regimen for advanced hepatocellular carcinoma (HCC) in Ch...
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Article
Metal-slag separation strengthening through in situ slagging during CuW composite preparation by metallothermic reduction
CuW is widely used in high-voltage electrical switch contacts, rocket nozzle throat linings, electronic packaging materials and other major high-end technologies. CuW is typically fabricated using infiltration...
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Article
Interfaces engineering of heterostructured NiCoP/NiFe LDH@CC for attaining high catalytic activity in long-lasting rechargeable Zn–air batteries
Zinc–air batteries (ZABs) offer tremendous potential in various industries and daily life due to their excellent energy density, safety and affordability. However, the practical application of ZABs has been se...
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Article
Open AccessComparative transcriptome analysis reveals genes involved in trichome development and metabolism in tobacco
The glandular trichomes of tobacco (Nicotiana tabacum) can efficiently produce secondary metabolites. They act as natural bioreactors, and their natural products function to protect plants against insect-pests an...
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Article
Stir-fried Semen Armeniacae Amarum Suppresses Aristolochic Acid I-Induced Nephrotoxicity and DNA Adducts
To investigate the protective effects of stir-fried Semen Armeniacae Amarum (SAA) against aristolochic acid I (AAI)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for ensur...
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Article
Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease
Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...
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Article
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
The blood–brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2–4. However, the m...
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Article
Creation of memory–memory entanglement in a metropolitan quantum network
Towards realizing the future quantum internet1,2, a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive multi-node set-ups on large sca...
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Article
Research progress in agricultural bioactive phosphonate esters compounds
Phosphonate structures in phosphonate compounds are biologically active organic synthetic materials derived from natural products. Due to their unique carbon-phosphorus (C–P) bonds, phosphonate compounds are h...
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Article
Open AccessDynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.
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Article
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykini...
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Article
Open AccessOral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...
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Article
Open AccessCsn5 inhibits autophagy by regulating the ubiquitination of Atg6 and Tor to mediate the pathogenicity of Magnaporthe oryzae
Csn5 is subunit 5 of the COP9 signalosome (CSN), but the mechanism by which it strictly controls the pathogenicity of pathogenic fungi through autophagy remains unclear. Here, we found that Csn5 deficiency att...
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Article
Open AccessNanobiolubricant grinding: a comprehensive review
Minimum quantity lubrication (MQL), which considers the cost, sustainability, flexibility, and quality, has been actively explored by scholars. Nanoadditive phases have been widely investigated as atomizing me...
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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Open AccessAnti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage...
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Article
Instability mechanism and energy evolution of surrounding rock at intersections of deep multi-form application
As mining progresses into deep strata, severe damage occurs at various long-life roadway intersections. To guide targeted repair and reinforcement operations, it is necessary to investigate the failure mechani...
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Article
Open AccessStudy on blasting fragmentation mechanism of burnt rock in open-pit coal mine
A large number of burnt rocks in some open-pit mines in **njiang, Inner Mongolia and Ningxia have a great influence on the blasting effect. For this kind of rock, through the analysis of physical and chemical ...
