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Open AccessIdentification and bioinformatics analysis of genes associated with pyroptosis in spinal cord injury of rat and mouse
The mechanism of spinal cord injury (SCI) is highly complex, and an increasing number of studies have indicated the involvement of pyroptosis in the physiological and pathological processes of secondary SCI. H...
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Article
Open AccessChiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds
C − N axially chiral compounds have recently attracted significant interest among synthetic chemistry community due to their widespread application in pharmaceuticals, advanced materials and organic synthesis....
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Article
Open AccessA non-image-forming visual circuit mediates the innate fear of heights in male mice
The neural basis of fear of heights remains largely unknown. In this study, we investigated the fear response to heights in male mice and observed characteristic aversive behaviors resembling human height vert...
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Article
Creation of memory–memory entanglement in a metropolitan quantum network
Towards realizing the future quantum internet1,2, a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive multi-node set-ups on large sca...
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Article
Open AccessTailoring d-band center of high-valent metal-oxo species for pollutant removal via complete polymerization
Polymerization-driven removal of pollutants in advanced oxidation processes (AOPs) offers a sustainable way for the simultaneous achievement of contamination abatement and resource recovery, supporting a low-c...
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Article
Open AccessIn situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation
J-aggregation, an effective strategy to extend wavelength, has been considered as a promising method for constructing NIR-II fluorophores. However, due to weak intermolecular interactions, conventional J-aggre...
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Article
Open AccessDynamics of multipartite quantum steering for different types of decoherence channels
Multipartite quantum steering, a unique resource for asymmetric quantum network information tasks, is very fragile to the inevitable decoherence, which makes it useless for practical purposes. It is thus of im...
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Article
Open AccessEvolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance
It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis of 163 matched blo...
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Article
Open AccessA saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...
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Article
Open AccessDevelopment of high-energy non-aqueous lithium-sulfur batteries via redox-active interlayer strategy
Lithium-sulfur batteries have theoretical specific energy higher than state-of-the-art lithium-ion batteries. However, from a practical perspective, these batteries exhibit poor cycle life and low energy conte...
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Article
Open AccessA case of antiferrochirality in a liquid crystal phase of counter-rotating staircases
Helical structures continue to inspire, prompted by examples such as DNA double-helix and alpha-helix in proteins. Most synthetic polymers also crystallize as helices, which relieves steric clashes by twisting...
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Article
Open AccessThree chromosome-level duck genome assemblies provide insights into genomic variation during domestication
Domestic ducks are raised for meat, eggs and feather down, and almost all varieties are descended from the Mallard (Anas platyrhynchos). Here, we report chromosome-level high-quality genome assemblies for meat...
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Article
Open AccessPPDPF alleviates hepatic steatosis through inhibition of mTOR signaling
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease in the world, however, no drug treatment has been approved for this disease. Thus, it is urgent to find effective t...
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Article
Open AccessFUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer
Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. Howe...
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Article
Open AccessA flexible ultrasensitive optoelectronic sensor array for neuromorphic vision systems
The challenges of develo** neuromorphic vision systems inspired by the human eye come not only from how to recreate the flexibility, sophistication, and adaptability of animal systems, but also how to do so ...
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Open AccessApplication of 3D printed model for planning the endoscopic endonasal transsphenoidal surgery
The application of 3D printing in planning endoscopic endonasal transsphenoidal surgery is illustrated based on the analysis of patients with intracranial skull base diseases who received treatment in our depa...
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Open AccessSize-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids
Size selectivity is an important mechanism for molecular recognition based on the size difference between targets and non-targets. However, rational design of an artificial size-selective molecular recognition...
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Article
Open AccessAutonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no ...
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Article
Open AccessMicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1
Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenousl...
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Article
Open AccessTRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and the...