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Article
Enantioselective alkyl–alkyl coupling by Ni-catalysed asymmetric cross-hydrodimerization of alkenes
Saturated tertiary stereogenic carbon centres are common in small molecules and organic materials. Transition-metal-catalysed asymmetric alkyl–alkyl bond formation processes represent contemporary techniques f...
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Article
Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study
Membranous nephropathy (MN) is a rare complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). MN patients may develop nephrotic syndrome or even kidney failure, which ...
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Article
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG per...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Open AccessREEP3 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in pancreatic cancer
Receptor Expression-Enhancing Protein 3 (REEP3) serves as a pivotal enzyme crucial for endoplasmic reticulum (ER) clearance during mitosis and is implicated in the advancement of diverse malignancies. Nonethel...
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Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
The impact of previous abdominal surgery on colorectal cancer patients undergoing laparoscopic surgery
The current study aimed to investigate whether previous abdominal surgery (PAS) could affect the outcomes of colorectal cancer (CRC) surgery. We conducted the search strategy in three databases (PubMed, Embase...
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Article
Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research
To assess the use of evidence-based research (EBR) approach in randomized controlled trials (RCTs) of acupuncture-related therapies for primary dysmenorrhea (PD).
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Article
Simultaneously Improved Curing, Mechanical, Antioxidative Properties and Reduced ZnO Loading of Silica Filled NR Composites by Incorporation of Low-cost Crude Carbon Dots via Conventional Melt-milling Method
Rubbers or elastomers play an important role in hi-tech technology and civilian daily life because of their unique and strategical properties. Generally, the rubber additives are essential components for rubbe...
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Article
KAD: a knowledge formalization-based anomaly detection approach for distributed systems
Large-scale distributed systems are becoming key engines of the IT industry due to their scalability and extensibility. A distributed system often involves numerous complex interactions among components, suffe...
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Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
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Article
Open AccessStable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China
Stable carbon isotope composition (δ13Cp) can be used to estimate the changes in intrinsic water use efficiency (iWUE) in plants, which helps us to better understand plants’ response strategies to climate change....
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Article
Microstructure evolution and oxidation behavior of silicon-modified aluminide coatings on IN718 superalloy at 1000 °C
Due to the increased service temperature of turbine blades, the high temperature conditions seriously deteriorate the mechanical properties of nickel-based superalloys, thus it is necessary to prepare the anti...
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Article
Three stilbenes from pigeon pea with promising anti-methicillin-resistant Staphylococcus aureus biofilm formation activity
Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of t...
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Article
Map** and comparing the technology evolution paths of scientific papers and patents: an integrated approach for forecasting technology trends
Exploring the key technology evolution paths in specific technological domains is essential to stimulate the technological innovation of enterprises. There have been many methods to identify the technology evo...
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Article
Open AccessProprioceptive and olfactory deficits in individuals with Parkinson disease and mild cognitive impairment
Individuals with neurodegenerative diseases such as Parkinson disease (PD) and Alzheimer’s (AD) disease often present with perceptual impairments at an early clinical stage. Therefore, early identification and...
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Article
Open AccessStructural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system
Silent information regulator 2 (Sir2) proteins typically catalyze NAD+-dependent protein deacetylation. The recently identified bacterial Sir2 domain-containing protein, defense-associated sirtuin 2 (DSR2), recog...
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Article
Modulation of plasmacytoid dendritic cell and CD4+ T cell differentiation accompanied by upregulation of the cholinergic anti-inflammatory pathway induced by enterovirus 71
Enterovirus 71 (EV71) is a neurotropic enterovirus associated with hand, foot, and mouth disease (HFMD) fatalities. In this study, we investigated the impact of EV71 on plasmacytoid dendritic cells (pDCs) and CD4
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Article
Open AccessThe potential role of hydrogen sulfide in cancer cell apoptosis
For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathologi...
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Article
Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage
Primary aldosteronism is associated with various types of cardiovascular and cerebrovascular damage independently of hypertension. Although chronic hypertension and related cerebral arteriosclerosis are the ma...
