84 Result(s)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways

Qi-wen Han, Qian-hang Shao, **ao-tong Wang, Kai-li Ma… in Acta Pharmacologica Sinica (2024)

Article

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...

Yang Fu, Yong-Song Chen, Dai-Yang **a, **ao-Dan Luo… in npj Biofilms and Microbiomes (2024)

Article

First report of mulberry vein banding-associated virus infecting Nicotiana tabacum in China

Ning Jiang, Tian-hua Han, Xue-biao Yang, Can-hua Lu… in Journal of Plant Pathology (2023)

Article

Online risky behavior and sleep quality among Chinese college students: The chain mediating role of rumination and anxiety

This study explored the chain mediating effects of rumination and anxiety in the relationship between online risky behavior and sleep quality among Chinese college students. A sample of 1039 Chinese college st...

Wen-Fu Qiu, Jian-** Ma, Zhen-Yu **e, **ao-Tong **e, Cong-**ng Wang… in Current Psychology (2023)

Article

A prediction model to predict in-hospital mortality in patients with acute type B aortic dissection

Acute type B aortic dissection (ABAD) is a life-threatening cardiovascular disease. A practicable and effective prediction model to predict and evaluate the risk of in-hospital death for ABAD is required. The ...

Meng-meng Wang, Min-Tao Gai, Bao-zhu Wang… in BMC Cardiovascular Disorders (2023)

Article

A randomized trial of Trendelenburg position for acute moderate ischemic stroke

We aim to explore the effect of head-down position (HDP), initiated within 24 hours of onset, in moderate anterior circulation stroke patients with probable large artery atherosclerosis (LAA) etiology. This in...

Hui-Sheng Chen, Nan-Nan Zhang, Yu Cui, **ao-Qiu Li, Cheng-Shu Zhou… in Nature Communications (2023)

Article

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma

Sustained activation of hepatocyte growth factor (HGF)/c-MET signaling is a major driver of hepatocellular carcinoma (HCC) progression, but underlying mechanism is unclear. ArfGAP With SH3 Domain, Ankyrin Repe...

**ao-Lu Ma, Yan-Yan Nie, Su-Hong **e, Hui Zheng… in Experimental Hematology & Oncology (2023)

Article

Evaluation of an innovative mHealth-based integrated modality for smoking cessation in Chinese smokers: protocol for a randomized controlled trial

Develo** accessible, affordable, and effective approaches to smoking cessation is crucial for tobacco control. Mobile health (mHealth) based interventions have the potential to aid smokers in quitting, and i...

Shuilian Chu, Lin Feng, Yingting Zuo, Hang **g, Di Zhang… in BMC Public Health (2023)

Article

Single-cell biological network inference using a heterogeneous graph transformer

Single-cell multi-omics (scMulti-omics) allows the quantification of multiple modalities simultaneously to capture the intricacy of complex molecular mechanisms and cellular heterogeneity. Existing tools canno...

Anjun Ma, **aoying Wang, **gxian Li, Cankun Wang, Tong **ao… in Nature Communications (2023)

Article

Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii, and its C-14 hydroxyl group is often selected for modification to enhance both the bioavailability and antitumor efficacy. How...

Yifeng Zhang, Jie Gao, Lin Ma, Lichan Tu, Tianyuan Hu, **aoyi Wu… in Nature Communications (2023)

Article

Engineering the xylose metabolism in Schizochytrium sp. to improve the utilization of lignocellulose

Schizochytrium sp. is a heterotrophic, oil-producing microorganism that can efficiently produce lipids. However, the industrial production of bulk chemicals using Schizochytrium sp. is still not economically viab...

Ling-Ru Wang, Zi-Xu Zhang, Fang-Tong Nong… in Biotechnology for Biofuels and Bioproducts (2022)

Article

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal sq...

Zhi-Qiang Ma, Ying-Tong Feng, Kai Guo, Dong Liu… in Military Medical Research (2022)