-
Article
Enantioselective alkyl–alkyl coupling by Ni-catalysed asymmetric cross-hydrodimerization of alkenes
Saturated tertiary stereogenic carbon centres are common in small molecules and organic materials. Transition-metal-catalysed asymmetric alkyl–alkyl bond formation processes represent contemporary techniques f...
-
Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
-
Article
Open AccessHealth and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study
The ongoing global crisis of Higher Education (HE) institutions during the post-COVID-19 pandemic period has increased the likelihood of enduring psychological stressors for staff. This study aimed to identify...
-
Article
Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
To assess the effectiveness of Chinese herbal medicine (CHM) combined with adjuvant chemotherapy on myelosuppression for colorectal cancer (CRC) patients using network meta-analysis (NMA).
-
Article
Amphidiploid production of a distant hybrid Populus simonii × P. euphratica cv. ‘**aohuyang-1’ and resulting in phenotypic variation
Populus simonii × P. euphratica cv. ‘**aohuyang-1’ is an elite variety produced by distant hybridization between Populus section Tacamahaca and sect. Turanga. However, its highly gametic sterility makes it diffic...
-
Article
Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks
Accessing high-order multiphoton excited fluorescence (H-MPEF) materials is challenging yet and needs complicated synthesis procedures. In this study, we successfully assembled plasmonic Au nanorods (Au NRs) w...
-
Article
Open AccessThe effect of hyperlipidemia on overall survival in patients with cancer was differentiated by BMI and hyperlipidemia type
The impact of lipids on the overall survival (OS) of patients with malignancy has not yet been clarified. This study aimed to evaluate the effect of hyperlipidemia on the OS among Chinese patients based on Bod...
-
Article
Open AccessLight-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic pressure and the associated water flow. Corresponding expansion...
-
Article
Open AccessWnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma
The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling during asthma. Wnt5a has been implicated in various lung diseases, while its role in t...
-
Article
Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways
-
Article
Collaborative role of warm pool edge and ocean heat content in El Niño development: implications for the 1982/83 extreme El Niño
El Niño can cause global-scale climatic and socioeconomic impacts, but its forecast remains challenging. Ocean heat content (OHC) and warm pool eastern edge (WPE) in the equatorial Pacific are regarded as two ...
-
Article
Open AccessLigand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies
Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is hel** to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmace...
-
Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
-
Article
Measurement and comparison of nutrients, bioactivity of four wild edible plants from Apiaceae family
In this experiment, four wild edible plants of Apiaceae species were studied, and their morphological indexes, ash, polysaccharide, protein, fat and mineral contents were determined. Significant variations were f...
-
Article
Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis
Primary angle-closure glaucoma (PACG) is a sight-threatening eye condition that leads to irreversible blindness. While past neuroimaging research has identified abnormal brain function in PACG patients, the re...
-
Article
Achieving high carrier mobility and low lattice thermal conductivity in GeTe-based alloys by cationic/anionic co-do**
The IV–VI compound GeTe is considered as a promising alternative to the toxic PbTe for high-efficiency mid-temperature thermoelectric applications. However, pristine GeTe suffers from a high concentration of G...
-
Article
Open AccessAtroposelective synthesis of biaxial bridged eight-membered terphenyls via a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization of phenols
Bridged chiral biaryls are axially chiral compounds with a medium-sized ring connecting the two arenes. Compared with plentiful methods for the enantioselective synthesis of biaryl compounds, synthetic approac...
-
Article
Open AccessBCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
BCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory multiple myeloma (RRMM), however, the current preparation process for autolog...
-
Article
Open AccessMild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy
Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment. This degradation is marked...
-
Article
Open AccessAuthor Correction: Historical changes in wind-driven ocean circulation drive pattern of Pacific warming
