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Article
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Article
Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Article
Open AccessA saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...
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Article
Analysis and Characterization of MADS-box Genes from Davidia involucrata Baill. and Regulation of Flowering Time in Arabidopsis
Davidia involucrata Baill. is a deciduous perennial tree. MADS-box genes are widely distributed in nature and play a key role in the growth and development of plants, especially in regulating the development of f...
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Article
MARK2 regulates chemotherapeutic responses through class IIa HDAC-YAP axis in pancreatic cancer
Despite paclitaxel’s wide use in cancer treatment, patient response rate is still low and drug resistance is a major clinical obstacle. Through a Phos-tag-based kinome-wide screen, we identified MARK2 as a cri...
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Article
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treat...
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Article
Discovery of a selective inhibitor of doublecortin like kinase 1
Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However, little is known about its potential as a...
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Article
Open AccessAssociations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
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Article
Sintering behavior of high-concentration Li2CO3-doped BaTiO3 ceramics
Li+ ion-doped BaTiO3 (LBT-x, x = 0, 3%, 5%, 7%) ceramics were prepared by the solid-state reaction method, which were analyzed by XRD and EDS. The Ba2TiO4 phase was formed on the surface of sintered LBT-x ceramic...
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Chapter and Conference Paper
The Sixth Visual Object Tracking VOT2018 Challenge Results
The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β
Cellular DNA repair processes are crucial to maintain genome stability and integrity. In DNA base excision repair, a tight heterodimer complex formed by DNA polymerase β (Polβ) and XRCC1 is thought to facilita...
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Article
Open AccessThe Physics of the B Factories
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Article
Open AccessInteractions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China
Existing literature indicates that ADRB2 gene is associated with health and longevity, but none of previous studies investigated associations of carrying the ADRB2 minor alleles and interactions between ADRB2 ...
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Article
Open AccessImpaired immune function in Gulf War Illness
Gulf War Illness (GWI) remains a serious health consequence for at least 11,000 veterans of the first Gulf War in the early 1990s. Our understanding of the health consequences that resulted remains inadequate,...
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Article
Poster abstracts
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Protocol
Recognition and Cleavage of Primary MicroRNA Transcripts
MicroRNAs (miRNAs) are approx 22-nucleotide (nt)-long, single-stranded, endogenous, noncoding RNAs that are widely expressed in multicellular organisms. This chapter describes methods that allow the overexpres...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
