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Open AccessThe Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment
Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these...
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Open AccessLegionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major fa...
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Open AccessIndividual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...
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Open AccessMolecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila
Toxin-antitoxin (TA) systems are ubiquitous genetic modules in bacteria and archaea. Here, we perform structural and biochemical characterization of the Legionella pneumophila effector Lpg2370, demonstrating that...
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Open AccessAged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcificati...
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Open AccessA bacterial kinase phosphorylates OSK1 to suppress stomatal immunity in rice
The Xanthomonas outer protein C2 (XopC2) family of bacterial effectors is widely found in plant pathogens and Legionella species. However, the biochemical activity and host targets of these effectors remain enigm...
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Open AccessAuthor Correction: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
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The efficacy and safety of microwave ablation versus lobectomy for the treatment of benign thyroid nodules greater than 4 cm
To evaluate the safety and effectiveness of microwave ablation (MWA) versus lobectomy for the treatment of benign thyroid nodules > 4 cm.
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Open AccessSensing of autoinducer-2 by functionally distinct receptors in prokaryotes
Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication within and between many bacterial species. However, its known receptors (LuxP and LsrB families) are not found in all the bacteria ca...
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Open AccessAuthor Correction: The Apostasia genome and the evolution of orchids
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessLegionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
The bacterial effector MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiquitin ligation, catalyzing formation of a γ-glutamyl-ε-Lys (Gln40Ub-Lys92Ube2N) isopeptide...
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Open AccessStructural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC
Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ...
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Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase
The bacterial pathogen Legionella pneumophila creates an intracellular niche permissive for its replication by extensively modulating host-cell functions using hundreds of effector proteins delivered by its Dot/I...
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Comparison and preliminary discussion of the reasons for the differences in diagnostic performance and unnecessary FNA biopsies between the ACR TIRADS and 2015 ATA guidelines
(1) To compare the American College of Radiology (ACR) thyroid imaging reporting and data system (TIRADS) and American Thyroid Association (ATA) guidelines for thyroid nodules with regard to diagnostic perform...
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Open AccessZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the adaptor MITA/STING to initiate innate antiviral respo...
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Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector
Ubiquitination is a post-translational modification that regulates many cellular processes in eukaryotes1–4. The conventional ubiquitination cascade culminates in a covalent linkage between the C terminus of ubiq...
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Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination
Conventional ubiquitination regulates key cellular processes by catalysing the ATP-dependent formation of an isopeptide bond between ubiquitin (Ub) and primary amines in substrate proteins 1 ...
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Open AccessSpectral features of the tunneling-induced transparency and the Autler-Townes doublet and triplet in a triple quantum dot
We theoretically investigate the spectral features of tunneling-induced transparency (TIT) and Autler-Townes (AT) doublet and triplet in a triple-quantum-dot system. By analyzing the eigenenergy spectrum of th...
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Open AccessDynamic profile of differentiated thyroid cancer in male and female patients with thyroidectomy during 2000–2013 in China: a retrospective study
The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors of differentiated thyroid carcinoma (DTC) in Chin...
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Open AccessObservation of the exceptional point in cavity magnon-polaritons
Magnon–polaritons are hybrid light–matter quasiparticles originating from the strong coupling between magnons and photons. They have emerged as a potential candidate for implementing quantum transducers and me...