-
Article
Open AccessThe Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment
Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these...
-
Article
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
-
Article
Open AccessYoung osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density ...
-
Article
Effect of short-time low-temperature austenitizing on microstructure and mechanical properties of DT300 ultra-high strength steel fabricated by laser powder bed fusion
To address the inhomogeneous microstructure and improve the mechanical properties of DT300 ultra-high strength steel specimens fabricated by laser powder bed fusion, different post-heat treatment schedules are...
-
Article
Open AccessLegionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major fa...
-
Article
Microstructure and magnetocaloric properties of melt-extracted SmGdDyCoAl high-entropy amorphous microwires
This paper presents a systematic investigation of the microstructure and magnetocaloric properties of melt-extracted Sm20Gd20Dy20Co20Al20 high-entropy microwires. The fabricated wires exhibited an amorphous struc...
-
Article
Open AccessLong-term outcome of children with acute promyelocytic leukemia: a randomized study of oral versus intravenous arsenic by SCCLG-APL group
Realgar-Indigo naturalis formula (RIF), an oral traditional Chinese medicine mainly containing Realgar (As4S4), is highly effective in treating adult acute promyelocytic leukemia (APL). However, the treatment eff...
-
Article
Alsobacter ponti sp. nov., a novel denitrification and sulfate reduction bacterium isolated from Pearl River sediment
A Gram-staining negative, aerobic, motile, and short rods strain, designated SYSU M60028T, was isolated from a Pearl River sediment sample in Guangzhou, Guangdong, China. The isolate could be able to grow at pH 6...
-
Article
Open AccessConsensus for criteria of running a pediatric inflammatory bowel disease center using a modified Delphi approach
Good quality of care for inflammatory bowel disease (IBD) depends on high-standard management and facility in the IBD center. Yet, there are no clear measures or criteria for evaluating pediatric IBD (PIBD) ce...
-
Article
Open AccessPRM-based quantitative proteomics analysis of altered HSP abundance in villi and decidua of patients with early missed abortion
In this study, we aimed to identify differentially expressed heat shock protein (HSP) profiles in the villi and decidua from patients with early missed abortion (EMA).
-
Article
Open AccessIndividual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...
-
Article
Open AccessEarly recombinant human growth hormone treatment improves mental development and alleviates deterioration of motor function in infants and young children with Prader–Willi syndrome
Recombinant human growth hormone (rhGH) therapy has shown to improve height and body composition in children with Prader–Willi syndrome (PWS), the evidence of early rhGH treatment on motor and mental developme...
-
Article
Open AccessWhether the Golgi protein 73 could be a diagnostic serological marker in hepatocellular carcinoma: a meta analysis
The Value of Golgi protein 73 (GP73) in the diagnosis of Hepatocellular carcinoma (HCC) remains controversial, especially in its differentiation between HCC and cirrhosis. Besides, some papers showed that GP73...
-
Article
Effect of static and dynamic misalignment of rolling bearing on nonlinear vibration characteristics of rotor system
In the research on rolling bearing misalignment, the influence of bearing misalignment on the vibration characteristics of the rotor system is rarely considered, especially for the dynamic bearing misalignment...
-
Article
Open AccessCorrection To: The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation
-
Article
Open AccessThe E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; its structural protein envelope (E) is critical...
-
Article
Open AccessCorrection: Differential diagnosis and feature visualization for thyroid nodules using computer-aided ultrasonic diagnosis system: initial clinical assessment
-
Article
Open AccessQCD improved top-quark decay at next-to-next-to-leading order
We analyse the top-quark decay at the next-to-next-to-leading order (NNLO) in QCD by using the Principle of Maximum Conformality (PMC) which provides a systematic way to eliminate renormalization scheme and sc...
-
Article
Open AccessHigh-precision map** reveals rare N6-deoxyadenosine methylation in the mammalian genome
N6-deoxyadenosine methylation (6mA) is the most widespread type of DNA modification in prokaryotes and is also abundantly distributed in some unicellular eukaryotes. However, 6mA levels are remarkably low in mam....
-
Article
Open AccessViral community-wide auxiliary metabolic genes differ by lifestyles, habitats, and hosts
Viral-encoded auxiliary metabolic genes (AMGs) are important toolkits for modulating their hosts’ metabolisms and the microbial-driven biogeochemical cycles. Although the functions of AMGs have been extensivel...
