-
Article
Open AccessTimelike bound orbits and pericenter precession around black hole with conformally coupled scalar hair
We investigate the geodesic motions of timelike particles around a static hairy black hole with conformally coupled scalar field. We mainly focus on the effects of the scalar charge and electric charge on the ...
-
Article
Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multi-Center, Phase-II Clinical Trial
To confirm the efficacy and safety of Ganyushu Granule (GYSG) in treating premenstrual syndrome (PMS) in patients with Gan (Liver) depression and qi stagnation syndrome (GDQSS) and determine its effective dosage.
-
Article
Open AccessReal-time predictive model of extrauterine growth retardation in preterm infants with gestational age less than 32 weeks
The aim of this study was to develop a real-time risk prediction model for extrauterine growth retardation (EUGR). A total of 2514 very preterm infants were allocated into a training set and an external valida...
-
Article
Mechanisms of cuproptosis and its relevance to distinct diseases
Copper is a trace element required by the organism, but once the level of copper exceeds the threshold, it becomes toxic and even causes death. The underlying mechanisms of copper-induced death are inconclusiv...
-
Article
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistanc...
-
Article
VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane
Vascular endothelial cells (VECs) are key players in the formation of neovessels and tumor metastasis, the ultimate cause of the majority of cancer-related human death. However, the crosstalk between VECs and ...
-
Article
Open AccessAdaptation mechanism of three Impatiens species to different habitats based on stem morphology, lignin and MYB4 gene
Impatiens is an important genus with rich species of garden plants, and its distribution is extremely extensive, which is reflected in its diverse ecological environment. However, the specific mechanisms of Impat...
-
Article
Open AccessPrecessing and periodic timelike orbits and their potential applications in Einsteinian cubic gravity
Einsteinian cubic gravity (ECG) is the most general theory up to cubic order in curvature, which has the same graviton spectrum as the Einstein theory. In this paper, we investigate the geodesic motions of tim...
-
Article
Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance
The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external forces. The polyurethane microcellular elastomers (PUMEs...
-
Article
Open AccessMetabolic landscape and pathogenic insights: a comprehensive analysis of high ovarian response in infertile women undergoing in vitro fertilization
In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hype...
-
Article
Open AccessDeficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
Hepatic encephalopathy (HE) is closely associated with inflammatory responses. However, as a crucial regulator of the immune and inflammatory responses, the role of leucine-rich repeat kinase 2 (LRRK2) in the ...
-
Article
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBi**g, a Chinese herb-based intravenous formulation
Sepsis, a life-threatening health issue, lacks effective medicine targeting the septic response. In China, treatment combining the intravenous herbal medicine XueBi**g with conventional procedures reduces the...
-
Article
Green manure substitution for potassium fertilizer promotes agro-ecosystem multifunctionality via triggering interactions among soil, plant and rhizosphere microbiome
Green manuring exhibits strong positive effects on soil fertility and crop yield, while its effects on agro-ecosystem multifunctionality (agro-EMF) and the underlying mechanisms are poorly understood.
-
Article
Open AccessOptofluidic crystallithography for directed growth of single-crystalline halide perovskites
Crystallization is a fundamental phenomenon which describes how the atomic building blocks such as atoms and molecules are arranged into ordered or quasi-ordered structure and form solid-state materials. While...
-
Article
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...
-
Article
Open AccessOverexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
This study aimed to explore the expression, molecular mechanism and its biological function of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer (BC).
-
Article
Interpretability Analysis of Shear Capacity in Reinforced Recycled Aggregate Concrete Beams Using Tree Models
Recycled aggregate concrete is an effective solution for efficiently managing municipal construction waste on a large scale. Shear bearing capacity (SBC) is significant for reinforced concrete structures, and ...
-
Article
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expressed in major dopaminergic areas and plays a crucial role in modulation of central dopamin...
-
Article
Open AccessMicrobial communities modulate chemical weathering and carbon dioxide cycling in an active orogen in Taiwan
Chemical weathering modulates carbon transfer between the crust, hydrosphere, and atmosphere. The extent to which microbial processes are involved in mineral dissolution remains elusive. Here, we performed geo...
-
Article
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway
To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis (RA).
