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Article
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Article
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of MSC-EVs pose a potential risk of thromboembolism, an issue tha...
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Article
Open AccessExamination of learning ability development through the implementation of the “autonomy-collaboration” learning mode grounded in evidence-based medicine practice
Currently, there are still some shortcomings in EBM education in China.The study aimed to investigate the effectiveness of the novel evidence-based medicine (EBM) learning model of “autonomy-collaboration.”
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Article
Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma
To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI.
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Article
A deep learning interatomic potential suitable for simulating radiation damage in bulk tungsten
So far, it has been a challenge for existing interatomic potentials to accurately describe a wide range of physical properties and maintain reasonable efficiency. In this work, we develop an interatomic potent...
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Article
Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor
The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is challenging. Herein, the carbon nanotubes (CNTs) coupled with ...
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Article
Open AccessATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) differentiation and function. Exactly how Wnt/β-catenin signaling is regulated in OBs remain...
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Article
Open AccessABA-mediated regulation of rice grain quality and seed dormancy via the NF-YB1-SLRL2-bHLH144 Module
Abscisic acid (ABA) plays a crucial role in promoting plant stress resistance and seed dormancy. However, how ABA regulates rice quality remains unclear. This study identifies a key transcription factor SLR1-l...
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Article
Open AccessSex difference in nocturnal blood pressure dip** in adolescents with varying degrees of adiposity
For adolescents, abnormal dip** patterns in blood pressure (BP) are associated with early-onset organ damage and a higher risk of cardiovascular disorders in adulthood. Obesity is one of the most common reas...
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Article
Open AccessComplete UV resonances of the dimension-8 SMEFT operators
The effective field theory approach parameterizes the low energy behaviors of all possible ultraviolet (UV) theories in a systematic way. One of the most important tasks is thus to find the connection between ...
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Article
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tumors, leading to resistance and poor prognosis. Activation of STAT3 signaling is freque...
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Article
Open AccessTrx4, a novel thioredoxin protein, is important for Toxoplasma gondii fitness
To successfully replicate within the host cell, Toxoplasma gondii employs several mechanisms to overcome the host cell defenses and mitigate the harmful effects of the free radicals resulting from its own metabol...
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Article
Contaminant transport modelling of heavy metal pollutants in soil and groundwater: An example at a non-ferrous smelter site
The topsoil of smelter sites is subjected to severe contamination by heavy metals (HMs). Existing numerical simulations typically treat soil and groundwater separately owing to data limitations and computation...
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Article
Open AccessSARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope (E) protein, a core virulence structural component of coron...
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Article
A Transformer-Assisted Cascade Learning Network for Choroidal Vessel Segmentation
As a highly vascular eye part, the choroid is crucial in various eye disease diagnoses. However, limited research has focused on the inner structure of the choroid due to the challenges in obtaining sufficient...
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Article
Microstructure and Mechanical Behavior of Mg-Based Bimetal Plates with High Formability Sleeve by Co-extrusion
In this study, microstructure and mechanical behavior of two types of Mg-based bimetal plates with a high formability sleeve were systematically studied, with a great emphasis on the effect of the interface ch...
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Article
Synthesis of Uniformly Covered Fe-MOF@COF Heterostructures for Boosting Photo-Fenton Catalysis
Fe-based MOFs (Fe-MOFs) are excellent photocatalysts and have synergy well with Fenton reagents relative to other MOFs. In this work, a series of uniformly covered NH2-Fe-MIL-88B@TpPa-1-COF composites were synthe...
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Article
Open AccessThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...
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Article
Open AccessPrognostic value of GLIM-defined malnutrition in combination with hand-grip strength or gait speed for the prediction of postoperative outcomes in gastric cancer patients with cachexia
Cancer cachexia is associated with impaired functional and nutritional status and worse clinical outcomes. Global Leadership Initiative in Malnutrition (GLIM) consensus recommended the application of GLIM crit...
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Article
The energy response of LaBr \(_{3}\) (Ce), LaBr \(_{3}\) (Ce,Sr), and NaI(Tl) crystals for GECAM
The GECAM series of satellites utilizes LaBr \(_3\) 3 ...
