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Article
Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications
Non-aromatic fluorescent and multi-responsive materials, exhibiting inherent fluorescence emission and controlled phase change, have garnered significant attention in recent years. However, the underlying inte...
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Article
Open AccessExpression patterns and evidence of the expansion of Nicotiana tabacum L. TALE genes in the Solanaceae family
The three-amino-acid-loop-extension (TALE) proteins are a class of transcription factors that regulate meristem differentiation during plant growth and development. In this study, we identified a total of 45 m...
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Article
Open AccessEffect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention
Previous studies have shown that low platelet count combined with high plasma total homocysteine (tHcy) increased stroke risk and can be lowered by 73% with folic acid. However, the combined role of other plat...
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Article
Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications
Owing to their high significance in fundamental study and diverse applications, stimuli-responsive and fluorescent polymers, particularly those with cluster-triggered emission (CTE) featured by non-conjugated ...
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Article
Resourceful preparation of Sb2O3 in hazardous As-Sb dust from typical lead smelter
Hazardous arsenic antimony dust (HAAD), a perilous by-product with significant antimony and arsenic concentrations generated in lead smelters, poses a substantial environmental threat. The imperative of resour...
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Article
Open AccessThe evolution and functional divergence of FT-related genes in controlling flowering time in Brassica rapa ssp. rapa
The BrrFT paralogues exhibit distinct expression patterns and play different roles in regulating flowering time, and BrrFT4 competes with BrrFT1 and BrrFT2 to interact with BrrFD proteins.
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Article
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become one of the hotspots in the development of anticancer therapies. Although significant pr...
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Article
Molecular solid solution of lanthanide-titanium-oxo clusters with enhanced photocatalytic hydrogen evolution
Molecular solid solutions of metal clusters containing different metal centers with well-defined structures can accurately regulate the HOMO-LUMO gap, but are rarely available. Herein, a series of colorless la...
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Article
Open AccessMolecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy
Procaspase 9 is the initiator caspase for apoptosis, but how its levels and activities are maintained remains unclear. The gigantic Inhibitor-of-Apoptosis Protein BIRC6/BRUCE/Apollon inhibits both apoptosis an...
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Article
Open AccessRGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic hete...
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Article
Megaelectronvolt electron acceleration driven by terahertz surface waves
Particles at relativistic energies form the basis of acceleration science. The emergence of terahertz-driven acceleration promises vastly smaller and cost-efficient accelerators; however, the field strength in...
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Article
Peak early diastolic strain rate improves prediction of adverse cardiovascular outcomes in patients with ST-elevation myocardial infarction
The prognostic role of diastolic dysfunction measured by the circumferential peak early diastolic strain rate (PEDSR) on ST-elevation myocardial infarction (STEMI) is not completely established.
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Article
Assessing the causal relationship between immune traits and systemic lupus erythematosus by bi-directional Mendelian randomization analysis
Previous studies have observed relationships between immune cells and systemic lupus erythematosus (SLE), but their causal links remain undetermined. Based on the public available genome-wide association studi...
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Article
Roux-en-Y and One-Anastomosis Gastric Bypass Surgery Are Superior to Sleeve Gastrectomy in Lowering Glucose and Cholesterol Levels Independent of Weight Loss: a Propensity-Score Weighting Analysis
The superior effects of gastric bypass surgery in preventing cardiovascular diseases compared with sleeve gastrectomy are well-established. However, whether these effects are independent of weight loss is not ...
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Article
The Aging Biomarker Consortium represents a new era for aging research in China
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Article
Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...
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Article
Verify the Function of a Potential Growth-Regulating Gene in Marine Bivalve Using a Candidate Model Organism Mulinia lateralis
A better understanding of genetic bases of growth regulation is essential for bivalve breeding, which is helpful to improve the yield of the commercially important bivalves. While previous studies have identif...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessSerum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model
Ménière’s disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although the role of immune responses in Ménière’s disease has been proposed, the pr...
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Article
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic ...
