13 Result(s)
within
**ao-Lan Wu
Life Sciences
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Article
Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity
The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discov...
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Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury
Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury. However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives interstitial inflamma...
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Article
Open AccessLncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization
Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal cancer (CRC) remain largely unknown. Besides, tumor-ass...
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Article
Open AccessCD45+CD33lowCD11bdim myeloid-derived suppressor cells suppress CD8+ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer
Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gast...
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Article
The Roles of Auxin in Regulating “Shoot Branching” of Cremastra appendiculata
Cremastra appendiculata (D. Don) Makino is a mainly vegetative propagation terrestrial orchid that is a typical representative of the warm-temperate vegetation in China. In this experimen...
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Open AccessMicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway
Gallbladder cancer (GBC) is a leading cause of cancer-related deaths worldwide, and its prognosis remains poor, with a 5-year survival rate of ~5%. Given the crucial role of microRNAs (miRNAs) in cancer metast...
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Article
Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring
Tree shrews have a close relationship to primates and have many advantages over rodents in biomedical research. However, the lack of gene manipulation methods has hindered the wider use of this animal. Spermat...
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Article
Phylogenetic relationship of two popular edible Pleurotus in China, Bailinggu (P. eryngii var. tuoliensis) and **ngbaogu (P. eryngii), determined by ITS, RPB2 and EF1α sequences
The aims of this study are to assess the utility of the internal transcribed spacer (ITS) region, and partial translation elongation factor (EF1α) and RNA polymerase II (RPB2) genes, for differentiation of Bai...
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Article
Identification of QTLs associated with salt or alkaline tolerance at the seedling stage in rice under salt or alkaline stress
The QTL analysis of dead leaf rate (DLR) and dead seedling rate (DSR) during the seedling stage under salt or alkaline stress were conducted, in order to provide the scientific basis for the fine map** and c...
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Article
Profiling of differentially expressed genes in ectomycorrhizal fungus Pisolithus tinctorius responding to mycorrhiza helper Brevibacillus reuszeri MPt17
A cDNA library of the ectomycorrhizal (ECM) fungus Pisolithus tinctorius Pt2 after interaction with the mycorrhiza helper bacterium (MHB) Brevibacillus reuszeri MPt17 was constructed by suppression subtraction hy...
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Article
Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein
The Notch signaling pathway has been implicated in the development of several leukemia and lymphoma. In order to investigate the relationship between Notch signaling and acute myeloid leukemia (AML), in this s...
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Article
Effects of mixing pine and broadleaved tree/shrub litter on decomposition and N dynamics in laboratory microcosms
This study was carried out to compare the ecological function of exotic pine (Pinus radiata—Pr) and native pine (Pinus tabulaeformis—Pt) in terms of litter decomposition and its related N dynamics and to evaluate...
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Article
Soil microbial biomass as affected by non-flooded plastic mulching cultivation in rice
The long-term field experiments were initiated in 2001 on five sites in Zhejiang province of China to monitor the impacts of non-flooded plastic mulching management on rice soil microbial biomass for sustainab...
