20 Result(s)

Article

Landform and lithospheric development contribute to the assembly of mountain floras in China

Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...

Wan-Yi Zhao, Zhong-Cheng Liu, Shi Shi, Jie-Lan Li, Ke-Wang Xu… in Nature Communications (2024)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonema...

Yumin Wang, Boya Gao, Luyuan Zhang, Xudong Wang, … in Nature Communications (2024)

Article

Drug-related problems in hospitalized patients with chronic kidney diseases and clinical pharmacist interventions

Patients with chronic kidney disease (CKD) are at high risk of drug-related problems (DRPs) because of extensive comorbidities and pharmacokinetic changes. This study aimed to identify DRPs and possible contri...

Su Zhang, Guo-bing Zhang, ** Huang, Yan Ren, Bo Lin, Yan-fei Shao… in BMC Geriatrics (2023)

Article

Outcomes of surgery and subsequent therapy for central nervous system oligoprogression in EGFR-mutated NSCLC patients

Oligoprogression is an emerging issue in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, the surgical treatment for central nervous system (CNS) oligo...

Pang-Shuo Perng, Heng-Juei Hsu, Jung-Shun Lee… in World Journal of Surgical Oncology (2023)

Article

Interface-engineered ferroelectricity of epitaxial Hf_0.5Zr_0.5O₂ thin films

Ferroelectric hafnia-based thin films have attracted intense attention due to their compatibility with complementary metal-oxide-semiconductor technology. However, the ferroelectric orthorhombic phase is therm...

Shu Shi, Haolong **, Tengfei Cao, Weinan Lin, Zhongran Liu… in Nature Communications (2023)

Article

Effect of BIM expression on the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs

The role of Programmed Cell Death Ligand 1 (PD-L1) expression in predicting epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) efficacy remains controversial. Recent studies have highlighte...

Chang-Yao Chu, Chien-Yu Lin, Chien-Chung Lin, Chien-Feng Li… in Scientific Reports (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

The surgical resection of the primary tumor increases survival in patients with EGFR-mutant advanced non-small cell lung cancer: a tertiary center cohort study

Tumor resection could increase treatment efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). This stud...

Ying-Yuan Chen, Po-Lan Su, Wei-Li Huang, Chao-Chun Chang, Yi-Ting Yen… in Scientific Reports (2022)

Article

Effect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics

Intramuscular injection of anemoside B4 (AB4) has a superior therapeutic effect on clinical mastitis in lactating cows. Here, we explored AB4’s effect on milk whey in clinical mastitis-affected cows using prot...

Liu-hong Shen, Yue Zhang, Yu Shen, Zhe-tong Su, Shu-min Yu… in Scientific Reports (2022)

Article

The impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy

Neoadjuvant immunotherapy and chemotherapy have improved the major pathological response (MPR) in patients with early-stage operable non-small cell lung cancer (NSCLC). This study aimed to assess whether the p...

Po-Lan Su, Jung-Yueh Chen, Chang-Yao Chu, Yi-Lin Chen, Wan-Li Chen… in Scientific Reports (2022)

Article

Clinical characteristics and patient outcomes of molecular subtypes of small cell lung cancer (SCLC)

Recent studies have shown that according to the expression levels of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), and POU class 2 homeobox 3 (POU2F3), small cell lung cancer ...

**ao-Long Ding, Yi-Ge Su, Liang Yu, Zhou-Lan Bai… in World Journal of Surgical Oncology (2022)

Article

Correction: Recent development of AAV-based gene therapies for inner ear disorders

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yiyang Lan, Yong Tao, Yunfeng Wang, Junzi Ke, Qiuxiang Yang, **aoyi Liu… in Gene Therapy (2020)

Article

Lung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in rats

Long-term mechanical ventilation with hyperoxia can induce lung injury. General anesthesia is associated with a very high incidence of hyperoxaemia, despite it usually lasts for a relatively short period of ti...

**ao-**a Wang, **ao-Lan Sha, Yu-Lan Li, Chun-Lan Li, Su-Heng Chen… in BMC Anesthesiology (2020)

Article

Deciphering synergetic core-shell transformation from [Mo₆O₂₂@Ag₄₄] to [Mo₈O₂₈@Ag₅₀]

The structural transformation of high-nuclearity silver clusters from one to another induced by specific stimuli is of scientific significance in terms of both cluster synthesis and reactivity. Herein, we repo...

Zhi Wang, Hai-Feng Su, Chen-Ho Tung, Di Sun, Lan-Sun Zheng in Nature Communications (2018)

Article

CD45⁺CD33^lowCD11b^dim myeloid-derived suppressor cells suppress CD8⁺ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer

Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gast...

Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng… in Cell Death & Disease (2018)

Article

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Casey Ager, Matthew Reilley, Courtney Nicholas… in Journal for ImmunoTherapy of Cancer (2016)

Article

XXIV World Allergy Congress 2015

A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts

Heung-Man Lee, Il-Ho Park, Jae-Min Shin… in World Allergy Organization Journal (2016)

Article

Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population

Recent genome-wide and candidate gene association studies in large numbers of systemic lupus erythematosus (SLE) patients have suggested approximately 30 susceptibility genes. These genes are involved in three...

Hua Zhong, **ao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen… in Arthritis Research & Therapy (2011)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)