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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Open AccessCanagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...
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Article
Open AccessMeiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair
Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonema...
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Article
Open AccessDrug-related problems in hospitalized patients with chronic kidney diseases and clinical pharmacist interventions
Patients with chronic kidney disease (CKD) are at high risk of drug-related problems (DRPs) because of extensive comorbidities and pharmacokinetic changes. This study aimed to identify DRPs and possible contri...
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Article
Open AccessOutcomes of surgery and subsequent therapy for central nervous system oligoprogression in EGFR-mutated NSCLC patients
Oligoprogression is an emerging issue in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, the surgical treatment for central nervous system (CNS) oligo...
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Article
Realization of superhuman intelligence in microstrip filter design based on clustering-reinforcement learning
Microstrip filters are widely used in signal processing because of their light weight, compact structure and high reliability. Designing these filters is very time consuming, and a designer generally needs muc...
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Article
Open AccessInterface-engineered ferroelectricity of epitaxial Hf0.5Zr0.5O2 thin films
Ferroelectric hafnia-based thin films have attracted intense attention due to their compatibility with complementary metal-oxide-semiconductor technology. However, the ferroelectric orthorhombic phase is therm...
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Article
Open AccessEffect of BIM expression on the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
The role of Programmed Cell Death Ligand 1 (PD-L1) expression in predicting epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) efficacy remains controversial. Recent studies have highlighte...
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Article
Open AccessTransarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...
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Article
Open AccessThe surgical resection of the primary tumor increases survival in patients with EGFR-mutant advanced non-small cell lung cancer: a tertiary center cohort study
Tumor resection could increase treatment efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). This stud...
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Article
Open AccessEffect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics
Intramuscular injection of anemoside B4 (AB4) has a superior therapeutic effect on clinical mastitis in lactating cows. Here, we explored AB4’s effect on milk whey in clinical mastitis-affected cows using prot...
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Article
Open AccessThe impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy
Neoadjuvant immunotherapy and chemotherapy have improved the major pathological response (MPR) in patients with early-stage operable non-small cell lung cancer (NSCLC). This study aimed to assess whether the p...
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Article
Open AccessClinical characteristics and patient outcomes of molecular subtypes of small cell lung cancer (SCLC)
Recent studies have shown that according to the expression levels of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), and POU class 2 homeobox 3 (POU2F3), small cell lung cancer ...
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Chapter and Conference Paper
Evaluation of Reasonable Productivity of Horizontal Wells in Offshore Carbonate Gas Reservoirs
1 exploration well has been drilled in the target gas field, and coring and production test have been carried out. It is planned to deploy a horizontal well in the high part of the gas reservoir for depletion ...
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Article
A novel co-amplification system for simultaneous amplification of 23 Y-STR and identification of spermatozoa
In alleged sexual assault cases, identification of the presence of spermatozoa at the crime scene, or on items of eventual significance, or associated with the body of the victim, is integral to the forensic i...
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Article
Correction: Recent development of AAV-based gene therapies for inner ear disorders
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessLung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in rats
Long-term mechanical ventilation with hyperoxia can induce lung injury. General anesthesia is associated with a very high incidence of hyperoxaemia, despite it usually lasts for a relatively short period of ti...
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Article
Combined effect of polymorphisms of MTHFR and MTR and arsenic methylation capacity on developmental delay in preschool children in Taiwan
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are related to cognitive dysfunction and mental disability. These genes, along with folate and vitamin B12 levels, are re...
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Article
Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan
Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbo...
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Article
Open AccessDeciphering synergetic core-shell transformation from [Mo6O22@Ag44] to [Mo8O28@Ag50]
The structural transformation of high-nuclearity silver clusters from one to another induced by specific stimuli is of scientific significance in terms of both cluster synthesis and reactivity. Herein, we repo...
