-
Article
Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
-
Article
Dynamin-related protein 1 mediates the therapeutic effect of isoliquiritigenin in diabetic intimal hyperplasia via regulation of mitochondrial fission
Phenotypic shift of vascular smooth muscle cells (VSMCs) plays a key role in intimal hyperplasia, especially in patients with diabetes mellitus (DM). This study aimed to investigate the role of dynamin-related...
-
Article
Typhoon-Induced Ocean Waves and Stokes Drift: A Case Study of Typhoon Mangkhut (2018)
Ocean waves and Stokes drift are generated by typhoons. This study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre ...
-
Article
Open AccessAssociation between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...
-
Article
Open AccessThe influence of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life of patients with sarcopenia receiving haemodialysis: a randomised controlled trial
To study the effect of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life in patients with sarcopenia receiving maintenance haemodialysis (...
-
Article
Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy
Migration is an initial step in tumor expansion and metastasis; suppressing cellular migration is beneficial to cancer therapy. Herein, we designed a novel biogated nanoagents that integrated the migration inh...
-
Article
Open AccessAn observable in Classical Pure AdS3 Gravity: the twist along a geodesic
In this paper, we consider a little-studied observable in classical pure AdS3 gravity: the twist along a geodesic. The motivation is that the twist only supports on the geodesic so may be a candidate element in t...
-
Article
Open AccessGlucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway
Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays a critical role in diabetes-related VC. Mitophagy ...
-
Article
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
Podocyte lipotoxicity mediated by impaired cellular cholesterol efflux plays a crucial role in the development of diabetic kidney disease (DKD), and the identification of potential therapeutic targets that reg...
-
Article
Open AccessThe Application of Aptamer and Research Progress in Liver Disease
Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such as antibodies, aptamers have the advantages of small molecular we...
-
Article
Experimental study on the influence mechanism of soil additives on scraper wear during EPB-TBM tunnelling in abrasive sandy ground
When earth pressure balance tunnel boring machines (EPB-TBMs) tunnelling in abrasive sandy ground, soil additives are critical for promoting excavation surface stability, reducing residual soil permeability, d...
-
Article
Open AccessEffects of appropriate low-temperature treatment on the yield and quality of pigmented potato (Solanum tuberosum L.) tubers
Temperature is one of the important environmental factors affecting plant growth, yield and quality. Moreover, appropriately low temperature is also beneficial for tuber coloration. The red potato variety Jian...
-
Article
Open AccessScreening and functional analysis of StMYB transcription factors in pigmented potato under low-temperature treatment
MYB transcription factors play an extremely important regulatory role in plant responses to stress and anthocyanin synthesis. Cloning of potato StMYB-related genes can provide a theoretical basis for the genetic ...
-
Article
Open AccessEffect of Postoperative Prolonged sedation with Dexmedetomidine after successful reperfusion with Endovascular Thrombectomy on long-term prognosis in patients with acute ischemic stroke (PPDET): study protocol for a randomized controlled trial
Endovascular thrombectomy (EVT) is a standard treatment for acute ischemic stroke (AIS) with large vessel occlusion. Hypertension and increased blood pressure variability within the first 24 h after successful...
-
Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
-
Article
Distribution characteristics of soil organic carbon fractions in paddy profiles with 40 years of fertilization under two groundwater levels
Soil organic carbon (SOC) storage in paddy profiles plays an important role in regulating terrestrial carbon cycling and global climatic change. The changes in groundwater level may influence the accumulation ...
-
Article
Fungal diversity notes 1717–1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa
As the continuation of Fungal Diversity Notes series, the current paper is the 16th contribution to this series. A total of 103 taxa from seven classes in Ascomycota and Basidiomycota are included here. Of these ...
-
Article
Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report
Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging chan...
-
Article
Open AccessSupplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA
The γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and progression of essential tremor (ET). However, the specific causative factor for...
-
Article
CDKN2B-AS1 mediates proliferation and migration of vascular smooth muscle cells induced by insulin
Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) contribute to the intimal hyperplasia in type 2 diabetes mellitus (T2DM) patients after percutaneous coronary intervention. We aime...
