162 Result(s)
within
**ao-Bo **
Biomedicine
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Article
Distribution of synapses on an intracellularly labeled small pyramidal neuron in the cat motor cortex
The morphological characteristics and distribution of synapses on a small pyramidal neuron in layer III of the cat motor cortex have been studied by combining intracellular HRP staining and electron microscopi...
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Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase
The cloned BK channel α subunit from human myometrium was stably expressed in Chinese hamster ovary cells, either alone (CHOα cells) or in combination with the auxiliary β subunit (CHOα+β cells). We studied b...
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Open AccessKnockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo
Breast cancer is the leading cause of cancer death in women worldwide. Elevated expression of c-Myc is a frequent genetic abnormality seen in this malignancy. For a better understanding of its role in maintain...
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Open AccessAnalysis of BKCa channel deficient mice
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Parameters selection in gene selection using Gaussian kernel support vector machines by genetic algorithm
In microarray-based cancer classification, gene selection is an important issue owing to the large number of variables and small number of samples as well as its non-linearity. It is difficult to get satisfyin...
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Article
Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis
Introduction: Experimental autoimmune encephalomyelitis (EAE) is a prototypic Th1-mediated autoimmune inflammatory disease of the central nervous system (CNS), and serves as a model for t...
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Article
C333H, a novel PPARα/γ dual agonist, has beneficial effects on insulin resistance and lipid metabolism
To examine the effects of novel peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist C333H on insulin resistance and lipid metabolism.
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Article
Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1
A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electrophysiological pr...
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Molecular addresses of tumors: selection by in vivo phage display
In vivo phage display has been used extensively to screen for novel targets of tumor therapy. Phage display peptide libraries can express random peptides or protein fragments and the aim of phage display is to id...
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Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues
N-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal an...
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Open AccessSpecificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities
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Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats
The overexpression of the human tissue kallikrein (HK) gene can reduce blood pressure and ameliorate the secondary syndromes associated with hypertension in animal models. The current study was designed to inv...
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Article
Spatial distribution of Cd and Cu in soils in Shenyang Zhangshi Irrigation Area (SZIA), China
Heavy metal contamination of soils, derived from sewage irrigation, mining and inappropriate utilization of various agrochemicals and pesticides, and so on, has been of wide concern in the last several decades...
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Article
Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells
To study the mechanism by which nanoparticle realgar powders (NRP) induce human histocytic lymphoma U937 cell apoptosis.
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Article
Investigation of non-covalent complexes of glutathione with common amino acids by electrospray ionization mass spectrometry
To study the non-covalent interaction between glutathione and common amino acids.
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Effects of RNA interference-induced tryptase down-regulation in P815 cells on IL-6 and TNF-α release of endothelial cells
To explore the effects of down-regulated tryptase expression in mast cells on the synthesis and release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) of vascular endothelial cells.
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Open AccessDorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling
The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at va...
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Article
Vesicular stomatitis virus matrix protein gene enhances the antitumor effects of radiation via induction of apoptosis
Vesicular stomatitis virus (VSV) matrix (M) protein can directly induce apoptosis by inhibiting host gene expression when it is expressed in the absence of other viral components. Previously, we found that the...
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Article
The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells
The aim of this study was to investigate the protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells and to begin a tentative discussion on the...
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Open AccessInhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice
Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than ...
