36 Result(s)
within
Biomedicine
Immunology
Internal Medicine
Pharmacology/Toxicology
**ao-Bo **
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Article
C333H, a novel PPARα/γ dual agonist, has beneficial effects on insulin resistance and lipid metabolism
To examine the effects of novel peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist C333H on insulin resistance and lipid metabolism.
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Article
Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats
The overexpression of the human tissue kallikrein (HK) gene can reduce blood pressure and ameliorate the secondary syndromes associated with hypertension in animal models. The current study was designed to inv...
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Article
Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells
To study the mechanism by which nanoparticle realgar powders (NRP) induce human histocytic lymphoma U937 cell apoptosis.
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Article
Investigation of non-covalent complexes of glutathione with common amino acids by electrospray ionization mass spectrometry
To study the non-covalent interaction between glutathione and common amino acids.
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Article
The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells
The aim of this study was to investigate the protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells and to begin a tentative discussion on the...
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Article
Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families
The goal of this study was to determine whether polymorphisms in the vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) genes are associated with variations of peak bone mineral density (BMD) and obesity...
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Article
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity
To investigate whether aspirin is able to augment gemcitabine-induced cytotoxicity in human pancreatic cancer cells.
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Article
L-carnitine and taurine synergistically inhibit the proliferation and osteoblastic differentiation of vascular smooth muscle cells
To investigate the synergistic action of L-carnitine (LC) and taurine (TAU) on the proliferation and osteoblastic differentiation of vascular smooth muscle cells (VSMCs).
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Article
Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats
To investigate the pharmacokinetic interactions induced by content variation of the main water-soluble components of Danshen injection in rats.
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Article
Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring
Genetic variation in ALOX12, which encoded human 12-lipoxygenase, was found to be associated with fat mass in young Chinese men. The objective of this study was to investigate the relationship between single n...
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Article
Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model
To investigate whether the stage of osteoarthritis (OA) progression influenced the efficacy of the third-generation bisphosphonate zoledronic acid in a rat medial meniscal tear model.
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Article
Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model
To investigate whether strontium ranelate (SR), a new antiosteoporotic agent, could attenuate cartilage degeneration and subchondral bone remodeling in osteoarthritis (OA).
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Article
Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice
To investigate whether apocynin, a NADPH oxidase inhibitor, produced cardioproteictive effects in Ang II-induced hypertensive mice, and to elucidate the underlying mechanisms.
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Article
Lapatinib-incorporated lipoprotein-like nanoparticles: preparation and a proposed breast cancer-targeting mechanism
Lapatinib is a dual inhibitor of EGFR and human epidermal growth factor receptor 2 (HER2), and used to treat advanced breast cancer. To overcome its poor water solubility, we constructed lapatinib-incorporated...
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Article
High throughput screening technologies for ion channels
Ion channels are involved in a variety of fundamental physiological processes, and their malfunction causes numerous human diseases. Therefore, ion channels represent a class of attractive drug targets and a c...
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Article
Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities
CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a ...
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Article
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine
Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-...
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Article
Chemokine CXCL13 activates p38 MAPK in the trigeminal ganglion after infraorbital nerve injury
Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitog...
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Article
Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine
l-Carnosine (β-alanyl-l-histidine) is a naturally occurring dipeptide distributed in various organs of mammalians. We previously showed that carnosine inhibited proliferation of human gastric cancer cells through...
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Article
Identification of PRDX6 as a regulator of ferroptosis
Ferroptosis is a newly characterized iron-dependent form of nonapoptotic regulated cell death triggered by lipid reactive oxygen species (LOOH). The dysregulation of ferroptosis is highly related to cancer, an...
