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  1. No Access

    Article

    The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

    Bao-Liang Song and colleagues report that the clathrin adaptor Numb recognizes a peptide motif within the cholesterol transporter NPC1L1 upon cholesterol binding and thus facilitates dietary cholesterol uptake...

    Pei-Shan Li, Zhen-Yan Fu, Ying-Yu Zhang, **-Hui Zhang, Chen-Qi Xu… in Nature Medicine (2014)

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    Article

    Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system

    PtpA is a secreted mycobacterial protein and virulence factor. Liu and colleagues demonstrate that PtpA suppresses signaling by cells of the innate immune system by coopting the activity of host ubiquitin.

    **g Wang, Bing-** Li, Pu-Pu Ge, Jie Li, Qi Wang, George Fu Gao… in Nature Immunology (2015)

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    Article

    Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity

    Stroke is a multiphasic process in which initial cerebral ischemia is followed by secondary injury from immune responses to ischemic brain components. Here we demonstrate that peripheral CD11b+CD45+ myeloid cells...

    Qingkun Liu, Emily M. Johnson, Rachel K. Lam, Qian Wang, Hong Bo Ye… in Nature Immunology (2019)

  4. Article

    Antibody responses to SARS-CoV-2 in patients with COVID-19

    We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

    Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng… in Nature Medicine (2020)

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    Article

    IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor

    CD8+ T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular mechanisms by which CD8+ T cells are triggered to ente...

    Yuying Liu, Nannan Zhou, Li Zhou, **g Wang, Yabo Zhou, Tianzhen Zhang… in Nature Immunology (2021)