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  1. Article

    Open Access

    Modelling the impact of human behavior using a two-layer Watts-Strogatz network for transmission and control of Mpox

    This study aims to evaluate the effectiveness of mitigation strategies and analyze the impact of human behavior on the transmission of Mpox. The results can provide guidance to public health authorities on com...

    Qiaojuan Jia, Ling Xue, Ran Sui, Junqi Huo in BMC Infectious Diseases (2024)

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  2. Article

    Open Access

    Association of thrombocytopenia and infection in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention

    The impact of thrombocytopenia on infection in patients with ST-elevation myocardial infarction (STEMI) remains poorly understood.

    Litao Wang, Weijiang Su, **hua Xue, **ao Gong, Yining Dai… in BMC Cardiovascular Disorders (2021)

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  3. No Access

    Article

    An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways

    Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneratio...

    Ling-xue Tao, Sha-sha Ji, Dóra Szalóki, Tibor Kovács… in Acta Pharmacologica Sinica (2021)

  4. No Access

    Article

    Phase I, First-in-Human, Single and Multiple Ascending Dose- and Food-Effect Studies to Assess the Safety, Tolerability and Pharmacokinetics of a Novel Anti-hepatitis B Virus Drug, Bentysrepinine (Y101), in Healthy Chinese Subjects

    Bentysrepinine (Y101), a derivative of repensine (a compound isolated from Dichondra repens Forst), is a novel phenylalanine dipeptide currently under development for the treatment of hepatitis B virus (HBV). ...

    **aoxue Liu, Ling Xue, Hua Zhang, Qingqing Xu, Shichao Zhang… in Clinical Drug Investigation (2020)

  5. No Access

    Article

    Population pharmacokinetics of theophylline in adult Chinese patients with asthma and chronic obstructive pulmonary disease

    Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacoki...

    Yanjiao Ma, Ling Xue, **n Chen, Yingbo Kang… in International Journal of Clinical Pharmacy (2018)

  6. Article

    Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons

    Iron dyshomeostasis is one of the primary causes of neuronal death in Alzheimer's disease (AD). Huperzine A (HupA), a natural inhibitor of acetylcholinesterase (AChE), is a licensed anti-AD drug in China and a...

    Ling-xue Tao, **ao-tian Huang, Yu-ting Chen, **-can Tang… in Acta Pharmacologica Sinica (2016)

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  7. No Access

    Article

    Molecular alterations of EGFR in small intestinal adenocarcinoma

    Molecular testing for epidermal growth factor receptor (EGFR) mutations has recently become a standard practice for the management of patients with non-squamous none small cell lung cancer. Primary small intestin...

    Yan Wang, Cong-Qing Jiang, **g Guan… in International Journal of Colorectal Disease (2013)

  8. No Access

    Article

    DIM stimulates IFNγ gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways

    3,3′-Diindolylmethane (DIM) is a promising anticancer agent derived from Brassica vegetables, but the mechanisms of DIM action are largely unknown. We have shown that DIM can upregulate the expression and stimula...

    Ling Xue, Gary L Firestone, Leonard F Bjeldanes in Oncogene (2005)