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  1. Article

    Open Access

    Double promoter and tandem gene strategy for efficiently expressing recombinant FGF21

    Fibroblast growth factor 21 (FGF21) is a promising candidate for treating metabolic disorder diseases and has been used in phase II clinical trials. Currently, metabolic diseases are prevalent worldwide, under...

    Longying Liu, Nuoyi Ning, Simeng Xu, Dongqing Chen, Lu** Zhou… in Microbial Cell Factories (2024)

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  2. Article

    Open Access

    Identification of tagged glycans with a protein nanopore

    Structural complexity of glycans derived from the diversities in composition, linage, configuration, and branching considerably complicates structural analysis. Nanopore-based single-molecule sensing offers th...

    Minmin Li, Yuting **ong, Yuchen Cao, Chen Zhang, Yuting Li… in Nature Communications (2023)

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  3. No Access

    Article

    Preparation of monodispersed mesoporous silica using imidazolium ionic liquids under a neutral condition

    Mesoporous silica nanospheres (MSNs) have drawn great attention in recent years. In spite of good progress made in the past years, the acid or base catalysis is still the most common way to prepare monodispers...

    Fandong Meng, **anlong Ye, Wangsun Chen, Yi Qi, Zhimou Guo… in Journal of Porous Materials (2022)

  4. Article

    Open Access

    Slc2a6 regulates myoblast differentiation by targeting LDHB

    Type 2 diabetes mellitus is a global health problem. It often leads to a decline in the differentiation capacity of myoblasts and progressive loss of muscle mass, which in turn results in deterioration of skel...

    Xuan Jiang, Ninghan Feng, Yizhou Zhou, **anlong Ye… in Cell Communication and Signaling (2022)

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  5. No Access

    Article

    Effects of Quenching Temperature and Cooling Rate on the Microstructure and Mechanical Properties of U75V Rail Steel

    In order to investigate the effects of quenching temperature and cooling rate on the microstructure and mechanical properties of the U75V rail steel, Gleeble-3500 thermal simulator and tensile tester were appl...

    Yuzhe Lan, Gang Zhao, Yaowen Xu… in Metallography, Microstructure, and Analysis (2019)

  6. No Access

    Article

    FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy

    The aim of this study is to evaluate the role of fibroblast growth factor 21 (FGF21) in nonalcoholic fatty liver disease (NAFLD) and seek to determine if its therapeutic effect is through induction of autophag...

    Shenglong Zhu, Yunzhou Wu, **anlong Ye, Lei Ma… in Molecular and Cellular Biochemistry (2016)

  7. No Access

    Article

    Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway

    Previous studies reveal that fibroblast growth factor 21 (FGF21) sensitizes insulin to achieve a synergy in regulating glucose metabolism. Here, we report that insulin sensitizes FGF21 in regulating both gluco...

    Dan Yu, **anlong Ye, Qiang Wu, Shujie Li, Yongbi Yang, **jiao He, Yunye Liu… in Endocrine (2016)

  8. No Access

    Article

    Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice

    In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice.

    Pengfei Xu, Yingjie Zhang, Wenfei Wang, Qingyan Yuan… in Digestive Diseases and Sciences (2015)

  9. No Access

    Article

    Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice

    Fibroblast growth factor-21 (FGF-21) is a new member of the FGF family and potential drug candidate for the treatment of type 2 diabetes mellitus. However, FGF-21 protein has short half-life in vivo, which sev...

    **anlong Ye, Jianying Qi, Gui** Ren, Pengfei Xu, Yunzhou Wu, Shenglong Zhu… in Endocrine (2015)

  10. No Access

    Article

    A 2 n scaling scheme for signed RNS integers and its VLSI implementation

    High efficient implementation of scaling in residue number system (RNS) is one of the critical issues for the applications of RNS in digital signal processing (DSP) systems. In this paper, an efficient scaling...

    Shang Ma, JianHao Hu, YanLong Ye, Lin Zhang… in Science in China Series F: Information Sci… (2010)