13 Result(s)
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Article
miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2
Transcription of the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is subject to dual regulation by host factors and viral proteins. MicroRNAs (miRNAs) can regulate the expression of targe...
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Open AccessContrast media extravasation injury: a prospective observational cohort study
To identify the risk factors for moderate and severe contrast media extravasation and provide effective guidance to reduce the degree of extravasation injuries.
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Article
Genomic profiling informs diagnoses and treatment in vascular anomalies
Vascular anomalies are malformations or tumors of the blood or lymphatic vasculature and can be life-threatening. Although molecularly targeted therapies can be life-saving, identification of the molecular eti...
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Open AccessObesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis
Obesity has been widely reported to be associated with the disease progression of coronavirus disease 2019 (COVID-19); however, some studies have reported different findings. We conducted a systematic review a...
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Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds
In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. Afte...
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Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
A meta-analysis across ten pediatric autoimmune diseases reveals shared genetic architecture and novel susceptibility loci.
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Evidence for natural recombination in the capsid gene VP2 of Taiwanese goose parvovirus
To investigate the possible role of recombination in the evolution of Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV) in Taiwan, we analyzed a potentially significant recombination event that occurre...
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Open AccessAnalyzing and identifying novel B cell epitopes within Toxoplasma gondii GRA4
The identification of specific epitopes targeted by the host antibody response is important for understanding the natural response to infection and for the development of epitope-based marker vaccines and diag...
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Isolation and characterization of a Chinese strain of Tembusu virus from Hy-Line Brown layers with acute egg-drop syndrome in Fujian, China
Tembusu virus (TMUV) has been a causative agent of an acute egg-drop syndrome found in Chinese duck populations since at least 2010. In this paper, we report the characterization of a TMUV-like flavivirus (nam...
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Comparative analysis of cloned cDNAs encoding Chinese yellow cattle and Gansu black swine integrin receptors for foot-and-mouth disease virus
To analyze foot-and-mouth disease virus tropism and host range with respect to the integrin receptor, we cloned cDNAs encoding the integrin αν, β1, β3, β6 and β8 subunits from Chinese yellow cattle and Gansu b...
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Open AccessScreening and identification of novel B cell epitopes of Toxoplasma gondii SAG1
The identification of protein epitopes is useful for diagnostic purposes and for the development of peptide vaccines. In this study, the epitopes of Toxoplasma gondii SAG1 were identified using synthetic peptide ...
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Impairment of Monocyte-derived Dendritic Cells in Idiopathic Pulmonary Arterial Hypertension
With the development of immunology, the role of immune inflammation in idiopathic pulmonary arterial hypertension (IPAH) has attracted interest. Recently, it was discovered that dendritic cells, which are key ...
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Article
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes
The latency of human immunodeficiency virus type 1 (HIV-1) in resting primary CD4+ T cells is the major barrier for the eradication of the virus in patients on suppressive highly active antiretroviral therapy (HA...
